Differential changes in rat brain tryptophan, serotonin and tyrosine levels following acute aflatoxin B1 treatment

Female Sprague-Dawley rats were treated acutely (12-h) with aflatoxin B1 (100 micrograms/kg i.p.) or vehicle (10% acetone in 0.9% NaCl) and regional brain levels of tryptophan, serotonin and tyrosine were assayed. Brainstem but not cerebellar or cortical tyrosine levels were decreased in aflatoxin B...

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Veröffentlicht in:	Toxicology letters 1989-05, Vol.47 (2), p.173-177
Hauptverfasser:	Weekley, L.B, O'Rear, C.E, Kimbrough, T.D, Llewellyn, G.C
Format:	Artikel
Sprache:	eng
Schlagworte:	Aflatoxin B1 aflatoxins Aflatoxins - toxicity Animals Biological and medical sciences brain Brain - drug effects Brain - metabolism carcinogens Carcinogens - toxicity Female Injections, Intraperitoneal Medical sciences Plant poisons toxicology Rats Rats, Inbred Strains serotonin Serotonin - metabolism Toxicology tryptophan Tryptophan - metabolism tyrosine Tyrosine - metabolism
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Zusammenfassung:	Female Sprague-Dawley rats were treated acutely (12-h) with aflatoxin B1 (100 micrograms/kg i.p.) or vehicle (10% acetone in 0.9% NaCl) and regional brain levels of tryptophan, serotonin and tyrosine were assayed. Brainstem but not cerebellar or cortical tyrosine levels were decreased in aflatoxin B1-treated rats. Brain tryptophan was increased in all 3 brain regions by acute aflatoxin B1 treatment, while serotonin levels were unaltered in the cerebellum and cortex and decreased in the brainstem. These experiments indicate that acute aflatoxin B1 treatment differentially alters brain amino acids and serotonin and that changes in brain tryptophan, the serotonin precursor, do not parallel changes in brain serotonin.
ISSN:	0378-4274 1879-3169
DOI:	10.1016/0378-4274(89)90072-6