Effect of hexachlorocyclohexane on somatic and meiotic divisions in male Swiss mice [Toxicity]

Hexachlorocyclohexane (HCH) is extensively used in India to control agricultural pests and vector-borne diseases such as malaria, thus increasing the risk of human exposure. Recently, NIGAM et al. reported testicular granuloma, hyalinization and degenerative changes in the testes of HCH-fed mice. However, reports on the effect of HCH on chromosomal preparations from bone marrow and testes are lacking in the literature. In the present investigation an attempt has been made to pinpoint the effect of HCH on somatic and meiotic divisions and on chromosomes. Studies are further extended to elucidate whether the changes are permanent or reversible.