Exploring mucosal immunization with a recombinant influenza virus carrying an HIV-polyepitope in mice with pre-existing immunity to influenza

Highlights • Anti-vector immunity affects the immunogenicity of foreign epitopes in mice. • Vaginal immunization with recombinant influenza virus elicits HIV-specific immunity. • Vaginal immunization with recombinant virus overcomes preexisting vector immunity.

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Bibliographische Detailangaben
Veröffentlicht in:	Vaccine 2014-05, Vol.32 (21), p.2501-2506
Hauptverfasser:	Garulli, Bruno, Di Mario, Giuseppina, Stillitano, Maria Giuseppina, Kawaoka, Yoshihiro, Castrucci, Maria Rita
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome Administration, Intranasal Administration, Intravaginal AIDS AIDS vaccine AIDS Vaccines - immunology Allergy and Immunology Animals Antigens, Viral - immunology Applied microbiology Biological and medical sciences CD8+ T cell responses Epitopes - immunology Experiments Female Fundamental and applied biological sciences. Psychology Genetic Vectors - immunology HIV Human immunodeficiency virus Human immunodeficiency virus 1 Human viral diseases Immune system Immunity, Mucosal Immunization Infections Infectious diseases Influenza Influenza virus Lymphocytes Medical research Medical sciences Mice Mice, Inbred BALB C Microbiology Miscellaneous Mucosal immunity Orthomyxoviridae Peptides Pre-existing antibody Proteins Public health Recombinant Proteins - immunology Vaccination - methods Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Vaccines, Synthetic - immunology Vaccinia virus Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Viral vector Virology Viruses
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Beschreibung
Zusammenfassung:	Highlights • Anti-vector immunity affects the immunogenicity of foreign epitopes in mice. • Vaginal immunization with recombinant influenza virus elicits HIV-specific immunity. • Vaginal immunization with recombinant virus overcomes preexisting vector immunity.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2014.02.077