Antiviral Phenolic Compounds from Arundina gramnifolia

Five new phenolic compounds, gramniphenols C–G (1–5), and eight known compounds (6–13) were isolated from the whole plant of Arundina gramnifolia. Compounds 1, 4, and 5 showed anti-tobacco mosaic virus activity, with IC50 values of 20.8, 40.8, and 57.7 μM, respectively. Compounds 1–10 were also test...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2013-02, Vol.76 (2), p.292-296
Hauptverfasser:	Hu, Qiu-Fen, Zhou, Bin, Huang, Jian-Ming, Gao, Xue-Mei, Shu, Li-Dan, Yang, Guang-Yu, Che, Chun-Tao
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-HIV Agents - chemistry Anti-HIV Agents - isolation & purification Anti-HIV Agents - pharmacology Antiviral Agents - chemistry Antiviral Agents - isolation & purification Antiviral Agents - pharmacology Arundina Drugs, Chinese Herbal - chemistry Drugs, Chinese Herbal - isolation & purification Drugs, Chinese Herbal - pharmacology HIV-1 - drug effects Humans Inhibitory Concentration 50 Molecular Structure Nuclear Magnetic Resonance, Biomolecular Orchidaceae - chemistry Phenols - chemistry Phenols - isolation & purification Phenols - pharmacology Tobacco Mosaic Virus - drug effects
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Zusammenfassung:	Five new phenolic compounds, gramniphenols C–G (1–5), and eight known compounds (6–13) were isolated from the whole plant of Arundina gramnifolia. Compounds 1, 4, and 5 showed anti-tobacco mosaic virus activity, with IC50 values of 20.8, 40.8, and 57.7 μM, respectively. Compounds 1–10 were also tested for their anti-HIV-1 activity; compounds 2, 3, and 6 displayed anti-HIV-1 activity with therapeutic index values above 100:1.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np300727f