Lasionectrin, a Naphthopyrone from a Lasionectria sp

A new naphthopyrone derivative, lasionectrin (1), was isolated from fermentations of an Acremonium-like fungus provisionally identified as a Lasionectria sp. (Ascomycota, Hypocreales) and isolated from forest leaf litter from Equatorial Guinea. Its structure was determined by a combination of spectr...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2012-06, Vol.75 (6), p.1228-1230
Hauptverfasser:	El Aouad, Noureddine, Pérez-Moreno, Guiomar, Sánchez, Paula, Cantizani, Juan, Ortiz-López, Francisco Javier, Martín, Jesús, González-Menéndez, Víctor, Ruiz-Pérez, Luis M, González-Pacanowska, Dolores, Vicente, Francisca, Bills, Gerald, Reyes, Fernando
Format:	Artikel
Sprache:	eng
Schlagworte:	Antimalarials - blood Antimalarials - chemistry Antimalarials - isolation & purification Antimalarials - pharmacology Ascomycota Equatorial Guinea Humans Hypocreales - chemistry Inhibitory Concentration 50 Molecular Structure Naphthalenes - blood Naphthalenes - chemistry Naphthalenes - isolation & purification Naphthalenes - pharmacology Nuclear Magnetic Resonance, Biomolecular Parasitic Sensitivity Tests Plant Leaves - microbiology Plasmodium falciparum Plasmodium falciparum - drug effects Pyrones - blood Pyrones - chemistry Pyrones - isolation & purification Pyrones - pharmacology
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Beschreibung
Zusammenfassung:	A new naphthopyrone derivative, lasionectrin (1), was isolated from fermentations of an Acremonium-like fungus provisionally identified as a Lasionectria sp. (Ascomycota, Hypocreales) and isolated from forest leaf litter from Equatorial Guinea. Its structure was determined by a combination of spectroscopic techniques, including UV, (+)-HRESIMS, and 1D and 2D NMR spectroscopy, and comparison with published data for related fungal metabolites. Compound 1 inhibited the growth of Plasmodium falciparum with an IC50 value of 11 μM.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np3002942