Comparison of minichromosome maintenance proteins (MCM-3, MCM-7) and metallothioneins (MT-I/II, MT-III) expression in relation to clinicopathological data in ovarian cancer
Despite great progress in the understanding of ovarian cancer biology, clinicopathological data (i.e. grade, stage, histological type and residual disease after surgery) seem to be the most important prognostic factors. The present study aimed to investigate the relationship between expression of mi...
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| Veröffentlicht in: | Anticancer research 2013-12, Vol.33 (12), p.5375-5383 |
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| creator | Kobierzycki, Christopher Pula, Bartosz Skiba, Mateusz Jablonska, Karolina Latkowski, Krzysztof Zabel, Maciej Nowak-Markwitz, Ewa Spaczynski, Marek Kedzia, Witold Podhorska-Okolow, Marzena Dziegiel, Piotr |
| description | Despite great progress in the understanding of ovarian cancer biology, clinicopathological data (i.e. grade, stage, histological type and residual disease after surgery) seem to be the most important prognostic factors.
The present study aimed to investigate the relationship between expression of minichromosome maintenance proteins (MCM-3, MCM-7), metallothioneins (MT-I/II, MT-III), and Ki-67 in 103 ovarian cancer cases, mostly of the serous histological type.
Statistical analysis revealed strong positive correlations in the expression of MCM-3 vs. Ki-67 (r=0.492), MCM-7 vs. Ki-67 (r=0.651), and MCM-3 vs. MCM-7 (r=0.515) (all p |
| format | Article |
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The present study aimed to investigate the relationship between expression of minichromosome maintenance proteins (MCM-3, MCM-7), metallothioneins (MT-I/II, MT-III), and Ki-67 in 103 ovarian cancer cases, mostly of the serous histological type.
Statistical analysis revealed strong positive correlations in the expression of MCM-3 vs. Ki-67 (r=0.492), MCM-7 vs. Ki-67 (r=0.651), and MCM-3 vs. MCM-7 (r=0.515) (all p<0.0001). The Kruskal-Wallis test showed an association of increased expression of MCM-3 and Ki-67 with increasing grade of histological malignancy (p=0.0011, p=0.029, respectively). Regarding clinical progression, cytoplasmic MT-I/II expression was significantly higher in more advanced disease stages (III+IV vs. I+II; p=0.0247).
Due to the correlations shown here, the determination of MCM proteins as proliferation markers of ovarian cancer, should be strongly considered.</description><identifier>ISSN: 0250-7005</identifier><identifier>EISSN: 1791-7530</identifier><identifier>PMID: 24324072</identifier><language>eng</language><publisher>Greece</publisher><subject>Adult ; Aged ; Biomarkers, Tumor - metabolism ; Female ; Humans ; Metallothionein - metabolism ; Middle Aged ; Minichromosome Maintenance Proteins - metabolism ; Ovarian Neoplasms - metabolism ; Ovarian Neoplasms - pathology</subject><ispartof>Anticancer research, 2013-12, Vol.33 (12), p.5375-5383</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24324072$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kobierzycki, Christopher</creatorcontrib><creatorcontrib>Pula, Bartosz</creatorcontrib><creatorcontrib>Skiba, Mateusz</creatorcontrib><creatorcontrib>Jablonska, Karolina</creatorcontrib><creatorcontrib>Latkowski, Krzysztof</creatorcontrib><creatorcontrib>Zabel, Maciej</creatorcontrib><creatorcontrib>Nowak-Markwitz, Ewa</creatorcontrib><creatorcontrib>Spaczynski, Marek</creatorcontrib><creatorcontrib>Kedzia, Witold</creatorcontrib><creatorcontrib>Podhorska-Okolow, Marzena</creatorcontrib><creatorcontrib>Dziegiel, Piotr</creatorcontrib><title>Comparison of minichromosome maintenance proteins (MCM-3, MCM-7) and metallothioneins (MT-I/II, MT-III) expression in relation to clinicopathological data in ovarian cancer</title><title>Anticancer research</title><addtitle>Anticancer Res</addtitle><description>Despite great progress in the understanding of ovarian cancer biology, clinicopathological data (i.e. grade, stage, histological type and residual disease after surgery) seem to be the most important prognostic factors.
The present study aimed to investigate the relationship between expression of minichromosome maintenance proteins (MCM-3, MCM-7), metallothioneins (MT-I/II, MT-III), and Ki-67 in 103 ovarian cancer cases, mostly of the serous histological type.
Statistical analysis revealed strong positive correlations in the expression of MCM-3 vs. Ki-67 (r=0.492), MCM-7 vs. Ki-67 (r=0.651), and MCM-3 vs. MCM-7 (r=0.515) (all p<0.0001). The Kruskal-Wallis test showed an association of increased expression of MCM-3 and Ki-67 with increasing grade of histological malignancy (p=0.0011, p=0.029, respectively). Regarding clinical progression, cytoplasmic MT-I/II expression was significantly higher in more advanced disease stages (III+IV vs. I+II; p=0.0247).
Due to the correlations shown here, the determination of MCM proteins as proliferation markers of ovarian cancer, should be strongly considered.</description><subject>Adult</subject><subject>Aged</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Female</subject><subject>Humans</subject><subject>Metallothionein - metabolism</subject><subject>Middle Aged</subject><subject>Minichromosome Maintenance Proteins - metabolism</subject><subject>Ovarian Neoplasms - metabolism</subject><subject>Ovarian Neoplasms - pathology</subject><issn>0250-7005</issn><issn>1791-7530</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtLw0AUhYMotlb_gsyyBYN3HskkSwk-Ai1u6rrcphM7Mo-YmYr-J3-kCda1q3MWH_ecyzlJplSWNJUZh9NkCiyDVAJkk-QihDeAPC8Lfp5MmOBMgGTT5LvytsNeB--Ib4nVTjf73lsfvFXEonZROXSNIl3vo9IukPmqWqX8howiFwTdjlgV0Rgf99q7I7NO69u6HqjB1PWCqM-uVyEMANGO9MpgHH30pDFjqO8w7r3xr7pBQ3YYceT8x9ANHWnGCv1lctaiCerqqLPk5eF-XT2ly-fHurpbph0TIqaswVwoQCizNge1LVmBjAEFngHwVkpBy23LSyiKot0NhmZtIYpsK3PO8lbxWTL_vTv8_H5QIW6sDo0yBp3yh7Ch2ZBDgZb0f1TkEnJWCjmg10f0sLVqt-l6bbH_2vyNwX8ADx-F2g</recordid><startdate>201312</startdate><enddate>201312</enddate><creator>Kobierzycki, Christopher</creator><creator>Pula, Bartosz</creator><creator>Skiba, Mateusz</creator><creator>Jablonska, Karolina</creator><creator>Latkowski, Krzysztof</creator><creator>Zabel, Maciej</creator><creator>Nowak-Markwitz, Ewa</creator><creator>Spaczynski, Marek</creator><creator>Kedzia, Witold</creator><creator>Podhorska-Okolow, Marzena</creator><creator>Dziegiel, Piotr</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>201312</creationdate><title>Comparison of minichromosome maintenance proteins (MCM-3, MCM-7) and metallothioneins (MT-I/II, MT-III) expression in relation to clinicopathological data in ovarian cancer</title><author>Kobierzycki, Christopher ; Pula, Bartosz ; Skiba, Mateusz ; Jablonska, Karolina ; Latkowski, Krzysztof ; Zabel, Maciej ; Nowak-Markwitz, Ewa ; Spaczynski, Marek ; Kedzia, Witold ; Podhorska-Okolow, Marzena ; Dziegiel, Piotr</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p244t-2ca64e0a095f60eb928a2201035003f77419bf390888fdf3915f8485b76326fe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Female</topic><topic>Humans</topic><topic>Metallothionein - metabolism</topic><topic>Middle Aged</topic><topic>Minichromosome Maintenance Proteins - metabolism</topic><topic>Ovarian Neoplasms - metabolism</topic><topic>Ovarian Neoplasms - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kobierzycki, Christopher</creatorcontrib><creatorcontrib>Pula, Bartosz</creatorcontrib><creatorcontrib>Skiba, Mateusz</creatorcontrib><creatorcontrib>Jablonska, Karolina</creatorcontrib><creatorcontrib>Latkowski, Krzysztof</creatorcontrib><creatorcontrib>Zabel, Maciej</creatorcontrib><creatorcontrib>Nowak-Markwitz, Ewa</creatorcontrib><creatorcontrib>Spaczynski, Marek</creatorcontrib><creatorcontrib>Kedzia, Witold</creatorcontrib><creatorcontrib>Podhorska-Okolow, Marzena</creatorcontrib><creatorcontrib>Dziegiel, Piotr</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Anticancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kobierzycki, Christopher</au><au>Pula, Bartosz</au><au>Skiba, Mateusz</au><au>Jablonska, Karolina</au><au>Latkowski, Krzysztof</au><au>Zabel, Maciej</au><au>Nowak-Markwitz, Ewa</au><au>Spaczynski, Marek</au><au>Kedzia, Witold</au><au>Podhorska-Okolow, Marzena</au><au>Dziegiel, Piotr</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of minichromosome maintenance proteins (MCM-3, MCM-7) and metallothioneins (MT-I/II, MT-III) expression in relation to clinicopathological data in ovarian cancer</atitle><jtitle>Anticancer research</jtitle><addtitle>Anticancer Res</addtitle><date>2013-12</date><risdate>2013</risdate><volume>33</volume><issue>12</issue><spage>5375</spage><epage>5383</epage><pages>5375-5383</pages><issn>0250-7005</issn><eissn>1791-7530</eissn><abstract>Despite great progress in the understanding of ovarian cancer biology, clinicopathological data (i.e. grade, stage, histological type and residual disease after surgery) seem to be the most important prognostic factors.
The present study aimed to investigate the relationship between expression of minichromosome maintenance proteins (MCM-3, MCM-7), metallothioneins (MT-I/II, MT-III), and Ki-67 in 103 ovarian cancer cases, mostly of the serous histological type.
Statistical analysis revealed strong positive correlations in the expression of MCM-3 vs. Ki-67 (r=0.492), MCM-7 vs. Ki-67 (r=0.651), and MCM-3 vs. MCM-7 (r=0.515) (all p<0.0001). The Kruskal-Wallis test showed an association of increased expression of MCM-3 and Ki-67 with increasing grade of histological malignancy (p=0.0011, p=0.029, respectively). Regarding clinical progression, cytoplasmic MT-I/II expression was significantly higher in more advanced disease stages (III+IV vs. I+II; p=0.0247).
Due to the correlations shown here, the determination of MCM proteins as proliferation markers of ovarian cancer, should be strongly considered.</abstract><cop>Greece</cop><pmid>24324072</pmid><tpages>9</tpages></addata></record> |
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| subjects | Adult Aged Biomarkers, Tumor - metabolism Female Humans Metallothionein - metabolism Middle Aged Minichromosome Maintenance Proteins - metabolism Ovarian Neoplasms - metabolism Ovarian Neoplasms - pathology |
| title | Comparison of minichromosome maintenance proteins (MCM-3, MCM-7) and metallothioneins (MT-I/II, MT-III) expression in relation to clinicopathological data in ovarian cancer |
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