Comparison of minichromosome maintenance proteins (MCM-3, MCM-7) and metallothioneins (MT-I/II, MT-III) expression in relation to clinicopathological data in ovarian cancer

Despite great progress in the understanding of ovarian cancer biology, clinicopathological data (i.e. grade, stage, histological type and residual disease after surgery) seem to be the most important prognostic factors. The present study aimed to investigate the relationship between expression of mi...

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Veröffentlicht in:	Anticancer research 2013-12, Vol.33 (12), p.5375-5383
Hauptverfasser:	Kobierzycki, Christopher, Pula, Bartosz, Skiba, Mateusz, Jablonska, Karolina, Latkowski, Krzysztof, Zabel, Maciej, Nowak-Markwitz, Ewa, Spaczynski, Marek, Kedzia, Witold, Podhorska-Okolow, Marzena, Dziegiel, Piotr
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Biomarkers, Tumor - metabolism Female Humans Metallothionein - metabolism Middle Aged Minichromosome Maintenance Proteins - metabolism Ovarian Neoplasms - metabolism Ovarian Neoplasms - pathology
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Zusammenfassung:	Despite great progress in the understanding of ovarian cancer biology, clinicopathological data (i.e. grade, stage, histological type and residual disease after surgery) seem to be the most important prognostic factors. The present study aimed to investigate the relationship between expression of minichromosome maintenance proteins (MCM-3, MCM-7), metallothioneins (MT-I/II, MT-III), and Ki-67 in 103 ovarian cancer cases, mostly of the serous histological type. Statistical analysis revealed strong positive correlations in the expression of MCM-3 vs. Ki-67 (r=0.492), MCM-7 vs. Ki-67 (r=0.651), and MCM-3 vs. MCM-7 (r=0.515) (all p
ISSN:	0250-7005 1791-7530