Broad heparin‐binding haemagglutinin‐specific cytokine and chemokine response in infants following Mycobacterium bovis BCG vaccination

Heparin‐binding haemagglutinin (HBHA)‐specific immune responses have been linked to protection against tuberculosis (TB). We investigated the hypothesis that BCG vaccination of human infants primes an HBHA‐specific response, using multiplex to measure secreted cytokines and chemokines following HBHA...

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Veröffentlicht in:	European journal of immunology 2012-09, Vol.42 (9), p.2511-2522
Hauptverfasser:	Smith, Steven G., Lecher, Sophie, Blitz, Rose, Locht, Camille, Dockrell, Hazel M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Antibodies, Bacterial - immunology Bacterial Proteins - immunology BCG vaccination BCG Vaccine - administration & dosage BCG Vaccine - immunology Chemokine CCL3 - immunology Chemokine CCL4 - immunology Chemokines Chemokines - immunology Cohort Studies Cytokines Heparin - immunology Heparin‐binding haemagglutinin (HBHA) Humans Immune system Infant Interferon-gamma - immunology Interleukins - immunology Membrane Proteins - immunology Mycobacterium bovis Mycobacterium bovis - immunology Mycobacterium tuberculosis Mycobacterium tuberculosis - immunology Tuberculin - immunology Tuberculosis Tuberculosis - immunology Tuberculosis - prevention & control Tumor Necrosis Factor-alpha - immunology
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