Viridaphin A sub(1) Glucoside, a Green Pigment Possessing Cytotoxic and Antibacterial Activity from the Aphid Megoura crassicauda

Viridaphin A sub(1) Glucoside, a Green Pigment Possessing Cytotoxic and Antibacterial Activity from the Aphid Megoura crassicauda

A green pigment, viridaphin A sub(1) glucoside (1), was isolated from the green aphid Megoura crassicauda. One- and two-dimensional NMR spectrometric analyses of 1 and its aglycone established the structure as an octacyclic compound. Viridaphin A sub(1) glucoside exhibited cytotoxicity against HL-60...

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Veröffentlicht in:Journal of natural products (Washington, D.C.) D.C.), 2011-08, Vol.74 (8), p.1812-1816-1812-1816
Hauptverfasser: Horikawa, Mitsuyo, Hoshiyama, To-sho, Matsuzawa, Masako, Shugyo, Takanori, Tanaka, Masami, Suzuki, Shinya, Sato, Masao, Ito, Takuya, Asakawa, Yoshinori, Kaku, Hiroto, Nishii, Takeshi, Inai, Makoto, Takahashi, Shigeru, Tsunoda, Tetsuto
Format: Artikel
Sprache:eng
Schlagworte:
Aphididae
Bacillus subtilis
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Zusammenfassung:A green pigment, viridaphin A sub(1) glucoside (1), was isolated from the green aphid Megoura crassicauda. One- and two-dimensional NMR spectrometric analyses of 1 and its aglycone established the structure as an octacyclic compound. Viridaphin A sub(1) glucoside exhibited cytotoxicity against HL-60 human tumor cells with an IC sub(50) of 23 mu M and antibacterial activity against Bacillus subtilis NBRC 3134 with a minimum inhibitory concentration of 10.0 mu g/mL. These results suggested that aphid pigments may protect aphids from invasive species, including viruses and bacteria.
ISSN:0163-3864
1520-6025
DOI:10.1021/np2001286