Heat shock protein gp96 adjuvant induces T cell responses and cross-protection to a split influenza vaccine
Highlights • We evaluate the efficiency of heat shock protein gp96-adjuvanted influenza vaccine. • gp96 Adjuvant enhances the immune response to the pH1N1 vaccine. • gp96 Elicited a cross-reactive CD8+ T cell response to the conserved viral protein NP. • gp96 Adjuvant effectively improves the cross-...
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| Veröffentlicht in: | Vaccine 2014-05, Vol.32 (23), p.2703-2711 |
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| container_issue | 23 |
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| container_title | Vaccine |
| container_volume | 32 |
| creator | Ju, Ying Fan, Hongxia Liu, Jun Hu, Jun Li, Xinghui Li, Changfei Chen, Lizhao Gao, Qiang Gao, George F Meng, Songdong |
| description | Highlights • We evaluate the efficiency of heat shock protein gp96-adjuvanted influenza vaccine. • gp96 Adjuvant enhances the immune response to the pH1N1 vaccine. • gp96 Elicited a cross-reactive CD8+ T cell response to the conserved viral protein NP. • gp96 Adjuvant effectively improves the cross-protection against heterologous influenza virus. • Our study reveals the potential use of gp96 adjuvant for pre-pandemic influenza vaccines. |
| doi_str_mv | 10.1016/j.vaccine.2014.03.045 |
| format | Article |
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Psychology ; gp96 ; Grants ; Heat shock proteins ; Heat-Shock Proteins - pharmacology ; Hemagglutination Inhibition Tests ; Immune system ; Immunity, Cellular ; Immunity, Humoral ; Immunization ; Influenza A Virus, H1N1 Subtype ; Influenza vaccine ; Influenza Vaccines - immunology ; Influenza virus ; Lymphocytes ; Mice, Inbred BALB C ; Microbiology ; Neutralization Tests ; Orthomyxoviridae Infections - prevention & control ; Pandemics ; Peptides ; Production capacity ; Swine flu ; T cell response ; Vaccines ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) ; Viruses</subject><ispartof>Vaccine, 2014-05, Vol.32 (23), p.2703-2711</ispartof><rights>Elsevier Ltd</rights><rights>2014 Elsevier Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2014 Elsevier Ltd. All rights reserved.</rights><rights>Copyright Elsevier Limited May 13, 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c511t-41a032eb5efa7eefb8476c963cddd6c84180d5386d6e4d5ddeec3dc85a427ee23</citedby><cites>FETCH-LOGICAL-c511t-41a032eb5efa7eefb8476c963cddd6c84180d5386d6e4d5ddeec3dc85a427ee23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0264410X14004149$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28438651$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24699472$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ju, Ying</creatorcontrib><creatorcontrib>Fan, Hongxia</creatorcontrib><creatorcontrib>Liu, Jun</creatorcontrib><creatorcontrib>Hu, Jun</creatorcontrib><creatorcontrib>Li, Xinghui</creatorcontrib><creatorcontrib>Li, Changfei</creatorcontrib><creatorcontrib>Chen, Lizhao</creatorcontrib><creatorcontrib>Gao, Qiang</creatorcontrib><creatorcontrib>Gao, George F</creatorcontrib><creatorcontrib>Meng, Songdong</creatorcontrib><title>Heat shock protein gp96 adjuvant induces T cell responses and cross-protection to a split influenza vaccine</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>Highlights • We evaluate the efficiency of heat shock protein gp96-adjuvanted influenza vaccine. • gp96 Adjuvant enhances the immune response to the pH1N1 vaccine. • gp96 Elicited a cross-reactive CD8+ T cell response to the conserved viral protein NP. • gp96 Adjuvant effectively improves the cross-protection against heterologous influenza virus. • Our study reveals the potential use of gp96 adjuvant for pre-pandemic influenza vaccines.</description><subject>Adjuvants, Immunologic - pharmacology</subject><subject>Allergy and Immunology</subject><subject>Aluminum</subject><subject>Animals</subject><subject>Antibodies, Viral - blood</subject><subject>Applied microbiology</subject><subject>Avian flu</subject><subject>Biological and medical sciences</subject><subject>CD8-Positive T-Lymphocytes - immunology</subject><subject>Conserved epitope</subject><subject>Cross Protection</subject><subject>Cytotoxicity</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>gp96</subject><subject>Grants</subject><subject>Heat shock proteins</subject><subject>Heat-Shock Proteins - pharmacology</subject><subject>Hemagglutination Inhibition Tests</subject><subject>Immune system</subject><subject>Immunity, Cellular</subject><subject>Immunity, Humoral</subject><subject>Immunization</subject><subject>Influenza A Virus, H1N1 Subtype</subject><subject>Influenza vaccine</subject><subject>Influenza Vaccines - immunology</subject><subject>Influenza virus</subject><subject>Lymphocytes</subject><subject>Mice, Inbred BALB C</subject><subject>Microbiology</subject><subject>Neutralization Tests</subject><subject>Orthomyxoviridae Infections - prevention & control</subject><subject>Pandemics</subject><subject>Peptides</subject><subject>Production capacity</subject><subject>Swine flu</subject><subject>T cell response</subject><subject>Vaccines</subject><subject>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</subject><subject>Viruses</subject><issn>0264-410X</issn><issn>1873-2518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkk9v1DAQxS0EotvCRwBZQki9bBj_3eRChSqgSJU4UCRulteegLNZJ8TJSuXT43QDlXqBkyXrNzNv3htCXjAoGDD9pikO1rkQseDAZAGiAKkekRUrN2LNFSsfkxVwLdeSwbcTcppSAwBKsOopOeFSV5Xc8BXZXaEdafrRuR3th27EEOn3vtLU-mY62DjSEP3kMNEb6rBt6YCp72LKHzZ66oYupfVdoRtDF-nYUUtT34a5sG4njL8sXZQ-I09q2yZ8vrxn5OuH9zeXV-vrzx8_Xb67XjvF2JgFWxActwpru0Gst6XcaFdp4bz32pWSleCVKLXXKL3yHtEJ70plJc88F2fk_Ng36_o5YRrNPqRZvI3YTckwxaUEWWY3_gNlglfAIKOvHqBNNw0xL5IpVmmuVDXPVkfqzpkBa9MPYW-HW8PAzMGZxix2mDk4A8Lk4HLdy6X7tN2j_1v1J6kMvF4Am5xt68FGF9I9V8rsiGKZuzhymB0-BBxMcgGjQx-GnJHxXfinlLcPOrg2xJCH7vAW0_3WJnED5st8ZfORMQkgmazEb7JTzlM</recordid><startdate>20140513</startdate><enddate>20140513</enddate><creator>Ju, Ying</creator><creator>Fan, Hongxia</creator><creator>Liu, Jun</creator><creator>Hu, Jun</creator><creator>Li, Xinghui</creator><creator>Li, Changfei</creator><creator>Chen, Lizhao</creator><creator>Gao, Qiang</creator><creator>Gao, George F</creator><creator>Meng, Songdong</creator><general>Elsevier Ltd</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7RV</scope><scope>7T2</scope><scope>7T5</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>7U2</scope></search><sort><creationdate>20140513</creationdate><title>Heat shock protein gp96 adjuvant induces T cell responses and cross-protection to a split influenza vaccine</title><author>Ju, Ying ; Fan, Hongxia ; Liu, Jun ; Hu, Jun ; Li, Xinghui ; Li, Changfei ; Chen, Lizhao ; Gao, Qiang ; Gao, George F ; Meng, Songdong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c511t-41a032eb5efa7eefb8476c963cddd6c84180d5386d6e4d5ddeec3dc85a427ee23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adjuvants, Immunologic - pharmacology</topic><topic>Allergy and Immunology</topic><topic>Aluminum</topic><topic>Animals</topic><topic>Antibodies, Viral - blood</topic><topic>Applied microbiology</topic><topic>Avian flu</topic><topic>Biological and medical sciences</topic><topic>CD8-Positive T-Lymphocytes - immunology</topic><topic>Conserved epitope</topic><topic>Cross Protection</topic><topic>Cytotoxicity</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>gp96</topic><topic>Grants</topic><topic>Heat shock proteins</topic><topic>Heat-Shock Proteins - pharmacology</topic><topic>Hemagglutination Inhibition Tests</topic><topic>Immune system</topic><topic>Immunity, Cellular</topic><topic>Immunity, Humoral</topic><topic>Immunization</topic><topic>Influenza A Virus, H1N1 Subtype</topic><topic>Influenza vaccine</topic><topic>Influenza Vaccines - immunology</topic><topic>Influenza virus</topic><topic>Lymphocytes</topic><topic>Mice, Inbred BALB C</topic><topic>Microbiology</topic><topic>Neutralization Tests</topic><topic>Orthomyxoviridae Infections - prevention & control</topic><topic>Pandemics</topic><topic>Peptides</topic><topic>Production capacity</topic><topic>Swine flu</topic><topic>T cell response</topic><topic>Vaccines</topic><topic>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ju, Ying</creatorcontrib><creatorcontrib>Fan, Hongxia</creatorcontrib><creatorcontrib>Liu, Jun</creatorcontrib><creatorcontrib>Hu, Jun</creatorcontrib><creatorcontrib>Li, Xinghui</creatorcontrib><creatorcontrib>Li, Changfei</creatorcontrib><creatorcontrib>Chen, Lizhao</creatorcontrib><creatorcontrib>Gao, Qiang</creatorcontrib><creatorcontrib>Gao, George F</creatorcontrib><creatorcontrib>Meng, Songdong</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nursing & Allied Health Database</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>Safety Science and Risk</collection><jtitle>Vaccine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ju, Ying</au><au>Fan, Hongxia</au><au>Liu, Jun</au><au>Hu, Jun</au><au>Li, Xinghui</au><au>Li, Changfei</au><au>Chen, Lizhao</au><au>Gao, Qiang</au><au>Gao, George F</au><au>Meng, Songdong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Heat shock protein gp96 adjuvant induces T cell responses and cross-protection to a split influenza vaccine</atitle><jtitle>Vaccine</jtitle><addtitle>Vaccine</addtitle><date>2014-05-13</date><risdate>2014</risdate><volume>32</volume><issue>23</issue><spage>2703</spage><epage>2711</epage><pages>2703-2711</pages><issn>0264-410X</issn><eissn>1873-2518</eissn><coden>VACCDE</coden><abstract>Highlights • We evaluate the efficiency of heat shock protein gp96-adjuvanted influenza vaccine. • gp96 Adjuvant enhances the immune response to the pH1N1 vaccine. • gp96 Elicited a cross-reactive CD8+ T cell response to the conserved viral protein NP. • gp96 Adjuvant effectively improves the cross-protection against heterologous influenza virus. • Our study reveals the potential use of gp96 adjuvant for pre-pandemic influenza vaccines.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>24699472</pmid><doi>10.1016/j.vaccine.2014.03.045</doi><tpages>9</tpages></addata></record> |
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| ispartof | Vaccine, 2014-05, Vol.32 (23), p.2703-2711 |
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| subjects | Adjuvants, Immunologic - pharmacology Allergy and Immunology Aluminum Animals Antibodies, Viral - blood Applied microbiology Avian flu Biological and medical sciences CD8-Positive T-Lymphocytes - immunology Conserved epitope Cross Protection Cytotoxicity Female Fundamental and applied biological sciences. Psychology gp96 Grants Heat shock proteins Heat-Shock Proteins - pharmacology Hemagglutination Inhibition Tests Immune system Immunity, Cellular Immunity, Humoral Immunization Influenza A Virus, H1N1 Subtype Influenza vaccine Influenza Vaccines - immunology Influenza virus Lymphocytes Mice, Inbred BALB C Microbiology Neutralization Tests Orthomyxoviridae Infections - prevention & control Pandemics Peptides Production capacity Swine flu T cell response Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Viruses |
| title | Heat shock protein gp96 adjuvant induces T cell responses and cross-protection to a split influenza vaccine |
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