Heat shock protein gp96 adjuvant induces T cell responses and cross-protection to a split influenza vaccine

Highlights • We evaluate the efficiency of heat shock protein gp96-adjuvanted influenza vaccine. • gp96 Adjuvant enhances the immune response to the pH1N1 vaccine. • gp96 Elicited a cross-reactive CD8+ T cell response to the conserved viral protein NP. • gp96 Adjuvant effectively improves the cross-protection against heterologous influenza virus. • Our study reveals the potential use of gp96 adjuvant for pre-pandemic influenza vaccines.