Heat shock protein complex vaccination induces protection against Helicobacter pylori without exogenous adjuvant

Highlights • Hsp complex vaccine induced protection against H. pylori without exogenous adjuvant. • First demonstration of protection by a mucosally delivered Hsp complex vaccine. • Hsp complex-induced protection was associated with increased gastric cytokines. • Hsp complex-induced protection was a...

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Veröffentlicht in:	Vaccine 2014-04, Vol.32 (20), p.2350-2358
Hauptverfasser:	Chionh, Yok Teng, Arulmuruganar, Arthi, Venditti, Elena, Ng, Garrett Z, Han, Jia-Xi, Entwisle, Claire, Ang, Ching-Seng, Colaco, Camilo A, McNulty, Shaun, Sutton, Philip
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic Allergy and Immunology Animals Antibodies, Bacterial - blood Applied microbiology Bacterial Proteins - immunology Bacterial Vaccines - immunology Bacteriology Biological and medical sciences Cytokines - immunology Female Fundamental and applied biological sciences. Psychology Gastric Mucosa - immunology Heat shock protein Heat-Shock Proteins - immunology Helicobacter Infections - prevention & control Helicobacter pylori Immunity, Mucosal Immunoglobulin A - immunology Immunoglobulin G - immunology Injections, Subcutaneous Mice Mice, Inbred C57BL Microbiology Miscellaneous Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
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Zusammenfassung:	Highlights • Hsp complex vaccine induced protection against H. pylori without exogenous adjuvant. • First demonstration of protection by a mucosally delivered Hsp complex vaccine. • Hsp complex-induced protection was associated with increased gastric cytokines. • Hsp complex-induced protection was associated with reduced gastritis severity.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2014.02.051