Impaired serotype-specific immune function following pneumococcal vaccination in infants with prior carriage

Highlights • Prior pneumococcal carriage impacts functional immunity in infants post-vaccination. • First study to demonstrate prior carriage impairs opsonophagocytic responses. • Implications early vaccine delivery prior to carriage onset to enhance protection.

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Bibliographische Detailangaben
Veröffentlicht in:	Vaccine 2014-04, Vol.32 (20), p.2321-2327
Hauptverfasser:	Licciardi, Paul V, Russell, Fiona M, Balloch, Anne, Burton, Robert L, Nahm, Moon H, Gilbert, Gwendolyn, Tang, Mimi L.K, Mulholland, Edward K
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Allergy and Immunology Antibodies, Bacterial - blood Antibody Specificity Applied microbiology Bacteriology Biological and medical sciences blood serum burden of disease Carriage Carrier State - immunology Confidence intervals Fiji Fundamental and applied biological sciences. Psychology Humans Hyporesponsiveness Immune response Immune system Immunization immunoglobulin G Immunoglobulin G - blood Infant Infants Microbiology Miscellaneous Nasopharynx - microbiology Opsonophagocytosis Phagocytosis Pneumococcal Pneumococcal Infections - prevention & control Pneumococcal Vaccines - administration & dosage Pneumonia polysaccharides PPS serotypes Serotyping Single-Blind Method Streptococcus infections Streptococcus pneumoniae Streptococcus pneumoniae - classification Time Factors vaccination Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
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Beschreibung
Zusammenfassung:	Highlights • Prior pneumococcal carriage impacts functional immunity in infants post-vaccination. • First study to demonstrate prior carriage impairs opsonophagocytic responses. • Implications early vaccine delivery prior to carriage onset to enhance protection.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2014.02.064