Fibrinogen as a therapeutic target for bleeding: a review of critical levels and replacement therapy

Fibrinogen plays a critical role in achieving and maintaining hemostasis and is fundamental to effective clot formation. There is increasing awareness of the important role of fibrinogen as a key target for the treatment and prevention of acquired bleeding. Fibrinogen is the first coagulation factor...

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Veröffentlicht in:	Transfusion (Philadelphia, Pa.) Pa.), 2014-05, Vol.54 (5), p.1389-1405
Hauptverfasser:	Levy, Jerrold H., Welsby, Ian, Goodnough, Lawrence T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Blood products Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis Factor VIII - therapeutic use Fibrinogen - administration & dosage Fibrinogen - analysis Fibrinogen - physiology Fibrinogen - therapeutic use Hemorrhage - blood Hemorrhage - drug therapy Hemorrhage - prevention & control Hemostasis Humans Medical sciences Orthopedic Procedures Plasma Transfusions. Complications. Transfusion reactions. Cell and gene therapy Wounds and Injuries - drug therapy
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Zusammenfassung:	Fibrinogen plays a critical role in achieving and maintaining hemostasis and is fundamental to effective clot formation. There is increasing awareness of the important role of fibrinogen as a key target for the treatment and prevention of acquired bleeding. Fibrinogen is the first coagulation factor to fall to critically low levels (
ISSN:	0041-1132 1537-2995
DOI:	10.1111/trf.12431