Androgen receptor as a regulator of ZEB2 expression and its implications in epithelial-to-mesenchymal transition in prostate cancer

Zinc finger E-box-binding protein 2 (ZEB2) is known to help mediate the epithelial-to-mesenchymal transition, and thereby it facilitates cancer metastasis. This study was initiated to explore whether ZEB2 expression differs in prostate cancer (PCa, n=7) and benign prostatic hyperplasia (BPH, n=7) ti...

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Veröffentlicht in:	Endocrine-related cancer 2014-06, Vol.21 (3), p.473-486
Hauptverfasser:	Jacob, Sheeba, Nayak, S, Fernandes, Gwendolyn, Barai, R S, Menon, S, Chaudhari, U K, Kholkute, S D, Sachdeva, Geetanjali
Format:	Artikel
Sprache:	eng
Schlagworte:	Androgens - pharmacology Apoptosis - drug effects Blotting, Western Cell Movement - drug effects Cell Proliferation - drug effects Dihydrotestosterone - pharmacology Epithelial-Mesenchymal Transition Fluorescent Antibody Technique Gene Expression Regulation, Neoplastic Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Humans Immunoenzyme Techniques Male MicroRNAs - genetics Neoplasms, Hormone-Dependent - drug therapy Neoplasms, Hormone-Dependent - genetics Neoplasms, Hormone-Dependent - metabolism Neoplasms, Hormone-Dependent - pathology Prostatic Hyperplasia - drug therapy Prostatic Hyperplasia - genetics Prostatic Hyperplasia - metabolism Prostatic Hyperplasia - pathology Prostatic Neoplasms - drug therapy Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Real-Time Polymerase Chain Reaction Receptors, Androgen - chemistry Receptors, Androgen - genetics Receptors, Androgen - metabolism Repressor Proteins - genetics Repressor Proteins - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Small Interfering - genetics Tumor Cells, Cultured Wound Healing Zinc Finger E-box Binding Homeobox 2
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Zusammenfassung:	Zinc finger E-box-binding protein 2 (ZEB2) is known to help mediate the epithelial-to-mesenchymal transition, and thereby it facilitates cancer metastasis. This study was initiated to explore whether ZEB2 expression differs in prostate cancer (PCa, n=7) and benign prostatic hyperplasia (BPH, n=7) tissues. In PCa tissues, the levels of both immunoreactive ZEB2 and androgen receptor (AR) were found to be significantly higher (P
ISSN:	1351-0088 1479-6821
DOI:	10.1530/ERC-13-0514