A Short Total Synthesis of the Marine Sponge Pyrrole-2-aminoimidazole Alkaloid (±)-Agelastatin A

Ring by ring: (±)‐Agelastatin A has been synthesized through the use of domino and one‐pot reactions while minimizing protecting group usage. The core was accessed through a stereoselective domino condensation/ring‐opening/4π‐conrotatory electrocyclization and elaborated using newly developed protocols for urea and amide formation. Oxidation of an unprotected pre‐agelastatin A and an intramolecular aza‐Michael reaction completed the synthesis in only six steps.