Vitamin E–gene interactions in aging and inflammatory age-related diseases: Implications for treatment. A systematic review

Highlights • The intake, absorption and distribution of Vitamin E within the body. • The role of Vitamin E in inflammatory/immune response in aging. • The role of Vitamin E in antioxidant response in aging. • The trials of Vitamin E in aging and age-related diseases with contradictory results. • The relevance of the Vitamin E–gene interactions for a personalized Vitamin E supplementation through nutrigenomic or nutrigenetic approaches in order to avoid Vitamin E adverse effects.