The network of P‐glycoprotein and microRNAs interactions

Overexpression of P‐glycoprotein (P‐gp) contributes to the multidrug resistance (MDR) phenotype found in many cancer cells. P‐gp has been identified as a promising molecular target, although attempts to find successful therapies to counteract its function as a drug efflux pump have largely failed to...

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Veröffentlicht in:	International journal of cancer 2014-07, Vol.135 (2), p.253-263
Hauptverfasser:	Lopes‐Rodrigues, Vanessa, Seca, Hugo, Sousa, Diana, Sousa, Emília, Lima, Raquel T., Vasconcelos, M. Helena
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism Biological and medical sciences Cancer Chemotherapy Drug resistance Drug Resistance, Multiple - physiology Drug Resistance, Neoplasm - physiology Drug therapy exosomes Gene Expression Regulation - physiology Glycoproteins Humans Medical research Medical sciences MicroRNAs MicroRNAs - metabolism microvesicles Multiple tumors. Solid tumors. Tumors in childhood (general aspects) P‐glycoprotein Signal Transduction - physiology Tumors
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