The network of P‐glycoprotein and microRNAs interactions

Overexpression of P‐glycoprotein (P‐gp) contributes to the multidrug resistance (MDR) phenotype found in many cancer cells. P‐gp has been identified as a promising molecular target, although attempts to find successful therapies to counteract its function as a drug efflux pump have largely failed to...

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Veröffentlicht in:International journal of cancer 2014-07, Vol.135 (2), p.253-263
Hauptverfasser: Lopes‐Rodrigues, Vanessa, Seca, Hugo, Sousa, Diana, Sousa, Emília, Lima, Raquel T., Vasconcelos, M. Helena
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Sprache:eng
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Zusammenfassung:Overexpression of P‐glycoprotein (P‐gp) contributes to the multidrug resistance (MDR) phenotype found in many cancer cells. P‐gp has been identified as a promising molecular target, although attempts to find successful therapies to counteract its function as a drug efflux pump have largely failed to date. Apart from its role in drug efflux, P‐gp may have other cellular functions such as being involved in apoptosis, and is found in various locations in the cell. Its expression is highly regulated, namely by microRNAs (miRNAs or miRs). In addition, P‐gp may regulate the expression of miRs in the cell. Furthermore, both P‐gp and miRs may be found in microvesicles or exosomes and may be transported to neighboring, drug‐sensitive cells. Here, we review this current issue together with recent evidence of this network of interactions between P‐gp and miRs.
ISSN:0020-7136
1097-0215
DOI:10.1002/ijc.28500