The network of P‐glycoprotein and microRNAs interactions
Overexpression of P‐glycoprotein (P‐gp) contributes to the multidrug resistance (MDR) phenotype found in many cancer cells. P‐gp has been identified as a promising molecular target, although attempts to find successful therapies to counteract its function as a drug efflux pump have largely failed to...
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| Veröffentlicht in: | International journal of cancer 2014-07, Vol.135 (2), p.253-263 |
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| container_title | International journal of cancer |
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| creator | Lopes‐Rodrigues, Vanessa Seca, Hugo Sousa, Diana Sousa, Emília Lima, Raquel T. Vasconcelos, M. Helena |
| description | Overexpression of P‐glycoprotein (P‐gp) contributes to the multidrug resistance (MDR) phenotype found in many cancer cells. P‐gp has been identified as a promising molecular target, although attempts to find successful therapies to counteract its function as a drug efflux pump have largely failed to date. Apart from its role in drug efflux, P‐gp may have other cellular functions such as being involved in apoptosis, and is found in various locations in the cell. Its expression is highly regulated, namely by microRNAs (miRNAs or miRs). In addition, P‐gp may regulate the expression of miRs in the cell. Furthermore, both P‐gp and miRs may be found in microvesicles or exosomes and may be transported to neighboring, drug‐sensitive cells. Here, we review this current issue together with recent evidence of this network of interactions between P‐gp and miRs. |
| doi_str_mv | 10.1002/ijc.28500 |
| format | Article |
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Helena</creatorcontrib><title>The network of P‐glycoprotein and microRNAs interactions</title><title>International journal of cancer</title><addtitle>Int J Cancer</addtitle><description>Overexpression of P‐glycoprotein (P‐gp) contributes to the multidrug resistance (MDR) phenotype found in many cancer cells. P‐gp has been identified as a promising molecular target, although attempts to find successful therapies to counteract its function as a drug efflux pump have largely failed to date. Apart from its role in drug efflux, P‐gp may have other cellular functions such as being involved in apoptosis, and is found in various locations in the cell. Its expression is highly regulated, namely by microRNAs (miRNAs or miRs). In addition, P‐gp may regulate the expression of miRs in the cell. Furthermore, both P‐gp and miRs may be found in microvesicles or exosomes and may be transported to neighboring, drug‐sensitive cells. Here, we review this current issue together with recent evidence of this network of interactions between P‐gp and miRs.</description><subject>Animals</subject><subject>ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism</subject><subject>Biological and medical sciences</subject><subject>Cancer</subject><subject>Chemotherapy</subject><subject>Drug resistance</subject><subject>Drug Resistance, Multiple - physiology</subject><subject>Drug Resistance, Neoplasm - physiology</subject><subject>Drug therapy</subject><subject>exosomes</subject><subject>Gene Expression Regulation - physiology</subject><subject>Glycoproteins</subject><subject>Humans</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>MicroRNAs</subject><subject>MicroRNAs - metabolism</subject><subject>microvesicles</subject><subject>Multiple tumors. Solid tumors. Tumors in childhood (general aspects)</subject><subject>P‐glycoprotein</subject><subject>Signal Transduction - physiology</subject><subject>Tumors</subject><issn>0020-7136</issn><issn>1097-0215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10N9KwzAUBvAgipvTC19ACiLoRbckTZrUuzH8MxkqsvuSpYlmdo0mLWN3PoLP6JOY2akgeJWL8-N8Jx8Ahwj2EYR4YOayjzmFcAt0EcxYDDGi26AbZjBmKEk7YM_7OYQIUUh2QQcThHGSkC44nz6pqFL10rrnyOro_uPt_bFcSfvibK1MFYmqiBZGOvtwO_SRqWrlhKyNrfw-2NGi9Opg8_bA9PJiOrqOJ3dX49FwEkvCScgnmGiSIMFSPSu4LiSjTBMECWIJlRoLnChBdYZTJmlGCsw5lIUIA06VSHrgtF0bLnptlK_zhfFSlaWolG18jmj4SZaxlAR6_IfObeOqcNxaIR4ieBrUWavCp7x3SucvziyEW-UI5us-89Bn_tVnsEebjc1soYof-V1gACcbILwUpXaiksb_Ok5STjELbtC6pSnV6v_EfHwzaqM_AZTviog</recordid><startdate>20140715</startdate><enddate>20140715</enddate><creator>Lopes‐Rodrigues, Vanessa</creator><creator>Seca, Hugo</creator><creator>Sousa, Diana</creator><creator>Sousa, Emília</creator><creator>Lima, Raquel T.</creator><creator>Vasconcelos, M. 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Helena</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4840-7424f431a76fbd8fdc757f41041735cf2a23ea5f9267c594d2880cdaf2a85ea3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Animals</topic><topic>ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism</topic><topic>Biological and medical sciences</topic><topic>Cancer</topic><topic>Chemotherapy</topic><topic>Drug resistance</topic><topic>Drug Resistance, Multiple - physiology</topic><topic>Drug Resistance, Neoplasm - physiology</topic><topic>Drug therapy</topic><topic>exosomes</topic><topic>Gene Expression Regulation - physiology</topic><topic>Glycoproteins</topic><topic>Humans</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>MicroRNAs</topic><topic>MicroRNAs - metabolism</topic><topic>microvesicles</topic><topic>Multiple tumors. Solid tumors. Tumors in childhood (general aspects)</topic><topic>P‐glycoprotein</topic><topic>Signal Transduction - physiology</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lopes‐Rodrigues, Vanessa</creatorcontrib><creatorcontrib>Seca, Hugo</creatorcontrib><creatorcontrib>Sousa, Diana</creatorcontrib><creatorcontrib>Sousa, Emília</creatorcontrib><creatorcontrib>Lima, Raquel T.</creatorcontrib><creatorcontrib>Vasconcelos, M. 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Helena</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The network of P‐glycoprotein and microRNAs interactions</atitle><jtitle>International journal of cancer</jtitle><addtitle>Int J Cancer</addtitle><date>2014-07-15</date><risdate>2014</risdate><volume>135</volume><issue>2</issue><spage>253</spage><epage>263</epage><pages>253-263</pages><issn>0020-7136</issn><eissn>1097-0215</eissn><coden>IJCNAW</coden><abstract>Overexpression of P‐glycoprotein (P‐gp) contributes to the multidrug resistance (MDR) phenotype found in many cancer cells. P‐gp has been identified as a promising molecular target, although attempts to find successful therapies to counteract its function as a drug efflux pump have largely failed to date. Apart from its role in drug efflux, P‐gp may have other cellular functions such as being involved in apoptosis, and is found in various locations in the cell. Its expression is highly regulated, namely by microRNAs (miRNAs or miRs). 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| subjects | Animals ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism Biological and medical sciences Cancer Chemotherapy Drug resistance Drug Resistance, Multiple - physiology Drug Resistance, Neoplasm - physiology Drug therapy exosomes Gene Expression Regulation - physiology Glycoproteins Humans Medical research Medical sciences MicroRNAs MicroRNAs - metabolism microvesicles Multiple tumors. Solid tumors. Tumors in childhood (general aspects) P‐glycoprotein Signal Transduction - physiology Tumors |
| title | The network of P‐glycoprotein and microRNAs interactions |
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