A Concise Colorimetric and Fluorimetric Probe for Sarin Related Threats Designed via the “Covalent-Assembly” Approach

A Concise Colorimetric and Fluorimetric Probe for Sarin Related Threats Designed via the “Covalent-Assembly” Approach

A turn-on signal from zero background allows sensitive detection of a weak signal and is highly desired. The “covalent-assembly” probe design principle is powerful in this regard. Herein, we report an embodiment of this principle (NA570) for detection of Sarin related threats, based on a phenylogous...

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Veröffentlicht in:Journal of the American Chemical Society 2014-05, Vol.136 (18), p.6594-6597
Hauptverfasser: Lei, Zuhai, Yang, Youjun
Format: Artikel
Sprache:eng
Schlagworte:
Chemical Warfare Agents - chemistry
Chemical Warfare Agents - toxicity
Colorimetry - methods
Fluorescent Dyes - chemistry
Sarin - chemistry
Sarin - toxicity
Spectrometry, Fluorescence
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Zusammenfassung:A turn-on signal from zero background allows sensitive detection of a weak signal and is highly desired. The “covalent-assembly” probe design principle is powerful in this regard. Herein, we report an embodiment of this principle (NA570) for detection of Sarin related threats, based on a phenylogous Vilsmeier–Haack reaction. NA570 bears a concise molecular construct, exhibits a colorimetric and a fluorimetric signal, and has potential for real applications.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja502945q