Adult neurogenesis: mechanisms and functional significance

New neurons are generated throughout life in distinct regions of the mammalian brain. This process, called adult neurogenesis, has been implicated in physiological brain function, and failing or altered neurogenesis has been associated with a number of neuropsychiatric diseases. Here, we provide an...

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Veröffentlicht in:	Development (Cambridge) 2014-05, Vol.141 (10), p.1983-1986
Hauptverfasser:	Braun, Simon M G, Jessberger, Sebastian
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Adult Stem Cells - physiology Animals Brain - cytology Brain - growth & development Brain - physiology Humans Mice Neural Stem Cells - physiology Neurogenesis - physiology Signal Transduction - physiology Stem Cell Niche - physiology
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Zusammenfassung:	New neurons are generated throughout life in distinct regions of the mammalian brain. This process, called adult neurogenesis, has been implicated in physiological brain function, and failing or altered neurogenesis has been associated with a number of neuropsychiatric diseases. Here, we provide an overview of the mechanisms governing the neurogenic process in the adult brain and describe how new neurons may contribute to brain function in health and disease.
ISSN:	0950-1991 1477-9129
DOI:	10.1242/dev.104596