Destination: inner nuclear membrane
Highlights • Multiple mechanisms, including diffusion-retention, may be involved in INM targeting. • Nuclear localization and INM sorting sequences are present on many INM proteins. • SUN and LEM domain proteins are targeted using a combination of transport pathways. • A Golgi retrieval sequence is...
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| Veröffentlicht in: | Trends in cell biology 2014-04, Vol.24 (4), p.221-229 |
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| container_title | Trends in cell biology |
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| creator | Katta, Santharam S Smoyer, Christine J Jaspersen, Sue L |
| description | Highlights • Multiple mechanisms, including diffusion-retention, may be involved in INM targeting. • Nuclear localization and INM sorting sequences are present on many INM proteins. • SUN and LEM domain proteins are targeted using a combination of transport pathways. • A Golgi retrieval sequence is required for INM localization of Sun2. • Non-canonical transport mechanisms may exist alongside NPC-dependent transport. |
| doi_str_mv | 10.1016/j.tcb.2013.10.006 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0962-8924 |
| ispartof | Trends in cell biology, 2014-04, Vol.24 (4), p.221-229 |
| issn | 0962-8924 1879-3088 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Active Transport, Cell Nucleus - physiology Animals Biosynthetic Pathways - physiology Humans inner nuclear membrane LEM domain Membrane Proteins - metabolism NPC Nuclear Envelope - metabolism Nuclear Pore Complex Proteins - metabolism nuclear transport Pathology Protein Binding - physiology SUN protein |
| title | Destination: inner nuclear membrane |
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