Destination: inner nuclear membrane

Highlights • Multiple mechanisms, including diffusion-retention, may be involved in INM targeting. • Nuclear localization and INM sorting sequences are present on many INM proteins. • SUN and LEM domain proteins are targeted using a combination of transport pathways. • A Golgi retrieval sequence is...

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Veröffentlicht in:	Trends in cell biology 2014-04, Vol.24 (4), p.221-229
Hauptverfasser:	Katta, Santharam S, Smoyer, Christine J, Jaspersen, Sue L
Format:	Artikel
Sprache:	eng
Schlagworte:	Active Transport, Cell Nucleus - physiology Animals Biosynthetic Pathways - physiology Humans inner nuclear membrane LEM domain Membrane Proteins - metabolism NPC Nuclear Envelope - metabolism Nuclear Pore Complex Proteins - metabolism nuclear transport Pathology Protein Binding - physiology SUN protein
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Highlights • Multiple mechanisms, including diffusion-retention, may be involved in INM targeting. • Nuclear localization and INM sorting sequences are present on many INM proteins. • SUN and LEM domain proteins are targeted using a combination of transport pathways. • A Golgi retrieval sequence is required for INM localization of Sun2. • Non-canonical transport mechanisms may exist alongside NPC-dependent transport.
ISSN:	0962-8924 1879-3088
DOI:	10.1016/j.tcb.2013.10.006