Rhodium-Catalyzed Synthesis of Isoquinolines and Indenes from Benzylidenehydrazones and Internal Alkynes

Rhodium-Catalyzed Synthesis of Isoquinolines and Indenes from Benzylidenehydrazones and Internal Alkynes

A new route is presented for the selective assembly of isoquinolines and indenes by rhodium-catalyzed tandem cyclization of benzylidenehydrazones with internal alkynes. This method involves the selective cleavage of the N–N bond and the CN bonds and is dependent on the substituents of the benzylide...

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Veröffentlicht in:Journal of organic chemistry 2014-02, Vol.79 (3), p.1025-1031
Hauptverfasser: Huang, Xiao-Cheng, Yang, Xu-Heng, Song, Ren-Jie, Li, Jin-Heng
Format: Artikel
Sprache:eng
Schlagworte:
Alkynes - chemistry
Catalysis
Hydrazines - chemistry
Indenes - chemical synthesis
Indenes - chemistry
Isoquinolines - chemical synthesis
Isoquinolines - chemistry
Molecular Structure
Rhodium - chemistry
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Beschreibung
Zusammenfassung:A new route is presented for the selective assembly of isoquinolines and indenes by rhodium-catalyzed tandem cyclization of benzylidenehydrazones with internal alkynes. This method involves the selective cleavage of the N–N bond and the CN bonds and is dependent on the substituents of the benzylidenehydrazone.
ISSN:0022-3263
1520-6904
DOI:10.1021/jo402497v