Acyclic Sulfides, Garlicnins L-1–L-4, E, and F, from Allium sativum

Six novel acyclic sulfides, named garlicnins L-1–L-4 (1–4), E (5), and F (6), were isolated from the acetone extracts, with the ability to suppress M2 macrophage activation, of the bulbs of garlic (Allium sativum L.), and their chemical structures were characterized.

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Bibliographische Detailangaben
Veröffentlicht in:	Chemical & pharmaceutical bulletin 2014/05/01, Vol.62(5), pp.477-482
Hauptverfasser:	Nohara, Toshihiro, Fujiwara, Yukio, Ikeda, Tsuyoshi, Yamaguchi, Koki, Manabe, Hideyuki, Murakami, Kotaro, Ono, Masateru, Nakano, Daisuke, Kinjo, Junei
Format:	Artikel
Sprache:	eng
Schlagworte:	acyclic sulfide Allium sativum Garlic - chemistry garlicnin E garlicnin F garlicnin L-1 Humans macrophage activation Macrophages - drug effects Molecular Structure Structure-Activity Relationship Sulfides - chemistry Sulfides - isolation & purification Sulfides - pharmacology Thiophenes - chemistry Thiophenes - isolation & purification Thiophenes - pharmacology
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Beschreibung
Zusammenfassung:	Six novel acyclic sulfides, named garlicnins L-1–L-4 (1–4), E (5), and F (6), were isolated from the acetone extracts, with the ability to suppress M2 macrophage activation, of the bulbs of garlic (Allium sativum L.), and their chemical structures were characterized.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.c14-00003