Iridium(I)-Catalyzed Direct CH Bond Alkylation of the C-7 Position of Indolines with Alkenes

Iridium(I)-Catalyzed Direct CH Bond Alkylation of the C-7 Position of Indolines with Alkenes

A cationic iridium‐catalyzed C‐7 alkylation of N‐substituted indoline derivatives with various alkenes has been developed. A variety of 7‐alkylindolines were obtained in moderate to high yields. This protocol relies on the use of the carbonyl group on the nitrogen atom of indoline as a directing gro...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Advanced synthesis & catalysis 2014-03, Vol.356 (5), p.929-933
Hauptverfasser: Pan, Shiguang, Ryu, Naoto, Shibata, Takanori
Format: Artikel
Sprache:eng
Schlagworte:
Alkenes
Alkylation
Bonding
Catalysis
Cationic
CH functionalization
Derivatives
iridium catalysts
N-substituted indolines
Nitrogen atoms
Synthesis
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:A cationic iridium‐catalyzed C‐7 alkylation of N‐substituted indoline derivatives with various alkenes has been developed. A variety of 7‐alkylindolines were obtained in moderate to high yields. This protocol relies on the use of the carbonyl group on the nitrogen atom of indoline as a directing group and it is potentially applicable to the large‐scale synthesis of 7‐alkylindoles.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.201300917