Preparation of 99Mo/99mTc generator based on alumina 99Mo-molybdate (VI) gel

In this work alumina 99 Mo-molybdate (VI) gel is evaluated as a column matrix for use in the preparation of small chromatographic column type 99m Tc generator. Alumina molybdate (VI) gel is prepared by dissolving inactive MoO 3 with aluminum foil in 5 M NaOH solution containing 99 Mo radiotracer. After complete dissolution, 0.5 H 2 O 2 was added to the reaction mixture solution and acidified to pH 5.5 with concentrated HNO 3 . The formed AlMo precipitate was washed with NaNO 3 solution, dried at 50 °C for 24 h and then packed in the form of a chromatographic column for elution of the generated 99m Tc radionuclide with physiological saline solution (0.9 % NaCl). Greater than 86 % of the generated 99m Tc activity is immediately and reproducibly eluted with passing 10 mL of the saline solution through 2.0 g of alumina 99 Mo-molybdate column bed at a flow rate of about 1.0 mL/min. The high radiochemical ≥98.6 % TcO 4 − , radionuclidic ≥99.90 % 99m Tc and chemical purities of the eluates satisfy the specifications for use in nuclear medicine.