Synthesis and antiproliferative activity of new cytotoxic tri- and tetraazabenzo[3,2-a]fluorene-5,6-dione derivatives

[Display omitted] A new series of substituted tri-/tetraazabenzo[3,2-a]fluorene-5,6-diones and their corresponding oxime derivatives have been synthesized and spectroscopically characterized. The antiproliferative activities of all compounds were evaluated on at least three different cell lines.

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Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2013-10, Vol.23 (19), p.5264-5266
Hauptverfasser:	Leepasert, Theerachart, Shahabi, Manochehr, Shanab, Karem, Schirmer, Eva, Holzer, Wolfgang, Spreitzer, Helmut, Aicher, Babette, Müller, Gilbert, Günther, Eckhard
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticancer compounds Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Aza Compounds - chemical synthesis Aza Compounds - chemistry Benzene Derivatives - chemical synthesis Benzene Derivatives - chemistry Cell Line, Tumor cell lines cell proliferation Cell Proliferation - drug effects chemical derivatives chemistry cytotoxicity cytotoxins Fluorenes - chemical synthesis Humans Inhibitory Concentration 50 Molecular Structure spectroscopy
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Beschreibung
Zusammenfassung:	[Display omitted] A new series of substituted tri-/tetraazabenzo[3,2-a]fluorene-5,6-diones and their corresponding oxime derivatives have been synthesized and spectroscopically characterized. The antiproliferative activities of all compounds were evaluated on at least three different cell lines.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2013.08.021