Diagnosis of Early Pancreas Graft Failure via Antibody‐Mediated Rejection: Single‐Center Experience With 256 Pancreas Transplantations

Diagnosis of Early Pancreas Graft Failure via Antibody‐Mediated Rejection: Single‐Center Experience With 256 Pancreas Transplantations

Early pancreas graft loss is usually attributed to technical failure while the possibility of antibody‐mediated rejection (AMR) is generally overlooked. To investigate the role of AMR in early pancreas graft loss, we retrospectively assessed 256 patients with simultaneous pancreas–kidney transplanta...

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Veröffentlicht in:American journal of transplantation 2014-04, Vol.14 (4), p.936-942
Hauptverfasser: de Kort, H., Mallat, M. J. K., van Kooten, C., de Heer, E., Brand‐Schaaf, S. H., van der Wal, A. M., Roufosse, C., Roelen, D. L., Bruijn, J. A., Claas, F. H., de Fijter, J. W., Bajema, I. M.
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Allografts
Antibodies
antibody‐mediated rejection
Biological and medical sciences
Case-Control Studies
Complement C4b - immunology
complement C4d
Female
Follow-Up Studies
graft rejection
Graft Rejection - diagnosis
Graft Rejection - etiology
Graft Rejection - mortality
histopathology
Humans
Immunity, Cellular - immunology
Isoantibodies - blood
Isoantibodies - immunology
Kidney Transplantation - adverse effects
Male
Medical sciences
Middle Aged
Pancreas
pancreas transplantation
Pancreas Transplantation - adverse effects
Pancreatic Diseases - complications
Pancreatic Diseases - surgery
Peptide Fragments - immunology
Postoperative Complications - diagnosis
Postoperative Complications - etiology
Postoperative Complications - mortality
Prognosis
Retrospective Studies
Risk Factors
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Survival Rate
Thrombosis - physiopathology
Tissue Donors
Transplants & implants
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Zusammenfassung:Early pancreas graft loss is usually attributed to technical failure while the possibility of antibody‐mediated rejection (AMR) is generally overlooked. To investigate the role of AMR in early pancreas graft loss, we retrospectively assessed 256 patients with simultaneous pancreas–kidney transplantation (SPK) between 1985 and 2010 at our institute. We included 33 SPK patients who lost their pancreas graft 1 month after transplantation in 6/7 cases, whereas all other causes typically led to loss
ISSN:1600-6135
1600-6143
DOI:10.1111/ajt.12624