Plant heat shock protein 90 as carrier-adjuvant for immunization against a reporter antigen
Highlights • We evaluate the adjuvant properties of heat shock protein 90 of Nicotiana benthamiana (NbHsp90.3). • Both humoral and cellular immune responses against MBP were elicited by administering the MBP-rNbHsp90.3 fusion protein. • The percentage of CD3+ CD8+ T cells significantly increased in...
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| Veröffentlicht in: | Vaccine 2013-12, Vol.31 (49), p.5872-5878 |
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| container_issue | 49 |
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| container_title | Vaccine |
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| creator | Corigliano, Mariana G Fenoy, Ignacio Sander, Valeria Maglioco, Andrea Goldman, Alejandra Clemente, Marina |
| description | Highlights • We evaluate the adjuvant properties of heat shock protein 90 of Nicotiana benthamiana (NbHsp90.3). • Both humoral and cellular immune responses against MBP were elicited by administering the MBP-rNbHsp90.3 fusion protein. • The percentage of CD3+ CD8+ T cells significantly increased in MBP-rNbHsp90.3-immunized mice. |
| doi_str_mv | 10.1016/j.vaccine.2013.09.047 |
| format | Article |
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Psychology ; Genes, MHC Class I ; heat shock proteins ; HSP90 Heat-Shock Proteins - immunology ; Immune response ; Immune system ; Immunity ; Immunity, Cellular ; Immunity, Humoral ; Immunization ; immunoglobulin G ; Immunoglobulin G - blood ; interferon-gamma ; Interferon-gamma - immunology ; Lymphocytes ; maltose ; Maltose-Binding Proteins - immunology ; Medical research ; Mice ; Mice, Inbred BALB C ; Microbiology ; Nicotiana - chemistry ; Nicotiana benthamiana ; Peptides ; Plant Hsp90 ; Plant Proteins - immunology ; Plasmids ; Proteins ; recombinant proteins ; Recombinant Proteins - immunology ; Spleen - cytology ; Spleen - immunology ; splenocytes ; Vaccine ; vaccines ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</subject><ispartof>Vaccine, 2013-12, Vol.31 (49), p.5872-5878</ispartof><rights>Elsevier Ltd</rights><rights>2013 Elsevier Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2013 Elsevier Ltd. All rights reserved.</rights><rights>Copyright Elsevier Limited Dec 2, 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c615t-9a9bb5846557fcae15806256daccfd0e9e5bd638aa86f0b0b7eeafbf5dd163a93</citedby><cites>FETCH-LOGICAL-c615t-9a9bb5846557fcae15806256daccfd0e9e5bd638aa86f0b0b7eeafbf5dd163a93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1552881524?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>315,782,786,3552,27931,27932,46002,64392,64394,64396,72476</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28010761$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24120680$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Corigliano, Mariana G</creatorcontrib><creatorcontrib>Fenoy, Ignacio</creatorcontrib><creatorcontrib>Sander, Valeria</creatorcontrib><creatorcontrib>Maglioco, Andrea</creatorcontrib><creatorcontrib>Goldman, Alejandra</creatorcontrib><creatorcontrib>Clemente, Marina</creatorcontrib><title>Plant heat shock protein 90 as carrier-adjuvant for immunization against a reporter antigen</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>Highlights • We evaluate the adjuvant properties of heat shock protein 90 of Nicotiana benthamiana (NbHsp90.3). • Both humoral and cellular immune responses against MBP were elicited by administering the MBP-rNbHsp90.3 fusion protein. • The percentage of CD3+ CD8+ T cells significantly increased in MBP-rNbHsp90.3-immunized mice.</description><subject>Adjuvant</subject><subject>adjuvants</subject><subject>Adjuvants, Immunologic - pharmacology</subject><subject>Allergy and Immunology</subject><subject>Animals</subject><subject>Antigens</subject><subject>Applied microbiology</subject><subject>binding proteins</subject><subject>Biological and medical sciences</subject><subject>CD8-positive T-lymphocytes</subject><subject>CD8-Positive T-Lymphocytes - immunology</subject><subject>cell-mediated immunity</subject><subject>Colleges & universities</subject><subject>cytotoxicity</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genes, MHC Class I</subject><subject>heat shock proteins</subject><subject>HSP90 Heat-Shock Proteins - immunology</subject><subject>Immune response</subject><subject>Immune system</subject><subject>Immunity</subject><subject>Immunity, Cellular</subject><subject>Immunity, Humoral</subject><subject>Immunization</subject><subject>immunoglobulin G</subject><subject>Immunoglobulin G - blood</subject><subject>interferon-gamma</subject><subject>Interferon-gamma - immunology</subject><subject>Lymphocytes</subject><subject>maltose</subject><subject>Maltose-Binding Proteins - immunology</subject><subject>Medical research</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Microbiology</subject><subject>Nicotiana - chemistry</subject><subject>Nicotiana benthamiana</subject><subject>Peptides</subject><subject>Plant Hsp90</subject><subject>Plant Proteins - immunology</subject><subject>Plasmids</subject><subject>Proteins</subject><subject>recombinant proteins</subject><subject>Recombinant Proteins - immunology</subject><subject>Spleen - cytology</subject><subject>Spleen - immunology</subject><subject>splenocytes</subject><subject>Vaccine</subject><subject>vaccines</subject><subject>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</subject><issn>0264-410X</issn><issn>1873-2518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkt1rFDEUxQdRbK3-CWpABF9mvclMvl4qUvyCgkItCD6EO5k722x3Z9ZkZqH-9WbY1UJfKgTy8rsn5-TconjOYcGBq7erxQ69Dz0tBPBqAXYBtX5QHHOjq1JIbh4WxyBUXdYcfhwVT1JaAYCsuH1cHImaC1AGjouf39bYj-yKcGTpavDXbBuHkULPLDBMzGOMgWKJ7WrazWQ3RBY2m6kPv3EMQ89wiaFPI0MWaTvEkSLLXFhS_7R41OE60bPDfVJcfvzw_exzef7105ez9-elV1yOpUXbNNLUSkrdeSQuDSghVZvzdS2QJdm0qjKIRnXQQKOJsGs62bZcVWirk-LNXjdb_zVRGt0mJE_rnIyGKTkuBVRacVP_B8qVlqCNuB-tpbVaCKUz-uoOuhqm2OfMWVAKY7KD-W25p3wcUorUuW0MG4w3joObO3Urd-jUzZ06sC53mudeHNSnZkPtv6m_JWbg9QHA5HHdRex9SLecAQ45fuZe7rkOB4fLmJnLi_ySBODacjsT7_YE5bp2uXeXfKDeUxsi-dG1Q7jX7OkdBb8Ofci2rumG0u2_uCQcuIt5RecN5RXMR1d_AJa4318</recordid><startdate>20131202</startdate><enddate>20131202</enddate><creator>Corigliano, Mariana G</creator><creator>Fenoy, Ignacio</creator><creator>Sander, Valeria</creator><creator>Maglioco, Andrea</creator><creator>Goldman, Alejandra</creator><creator>Clemente, Marina</creator><general>Elsevier Ltd</general><general>Elsevier</general><general>Elsevier Limited</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7RV</scope><scope>7T2</scope><scope>7T5</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20131202</creationdate><title>Plant heat shock protein 90 as carrier-adjuvant for immunization against a reporter antigen</title><author>Corigliano, Mariana G ; Fenoy, Ignacio ; Sander, Valeria ; Maglioco, Andrea ; Goldman, Alejandra ; Clemente, Marina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c615t-9a9bb5846557fcae15806256daccfd0e9e5bd638aa86f0b0b7eeafbf5dd163a93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adjuvant</topic><topic>adjuvants</topic><topic>Adjuvants, Immunologic - pharmacology</topic><topic>Allergy and Immunology</topic><topic>Animals</topic><topic>Antigens</topic><topic>Applied microbiology</topic><topic>binding proteins</topic><topic>Biological and medical sciences</topic><topic>CD8-positive T-lymphocytes</topic><topic>CD8-Positive T-Lymphocytes - immunology</topic><topic>cell-mediated immunity</topic><topic>Colleges & universities</topic><topic>cytotoxicity</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genes, MHC Class I</topic><topic>heat shock proteins</topic><topic>HSP90 Heat-Shock Proteins - immunology</topic><topic>Immune response</topic><topic>Immune system</topic><topic>Immunity</topic><topic>Immunity, Cellular</topic><topic>Immunity, Humoral</topic><topic>Immunization</topic><topic>immunoglobulin G</topic><topic>Immunoglobulin G - blood</topic><topic>interferon-gamma</topic><topic>Interferon-gamma - immunology</topic><topic>Lymphocytes</topic><topic>maltose</topic><topic>Maltose-Binding Proteins - immunology</topic><topic>Medical research</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Microbiology</topic><topic>Nicotiana - chemistry</topic><topic>Nicotiana benthamiana</topic><topic>Peptides</topic><topic>Plant Hsp90</topic><topic>Plant Proteins - immunology</topic><topic>Plasmids</topic><topic>Proteins</topic><topic>recombinant proteins</topic><topic>Recombinant Proteins - immunology</topic><topic>Spleen - cytology</topic><topic>Spleen - 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| ispartof | Vaccine, 2013-12, Vol.31 (49), p.5872-5878 |
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| subjects | Adjuvant adjuvants Adjuvants, Immunologic - pharmacology Allergy and Immunology Animals Antigens Applied microbiology binding proteins Biological and medical sciences CD8-positive T-lymphocytes CD8-Positive T-Lymphocytes - immunology cell-mediated immunity Colleges & universities cytotoxicity Female Fundamental and applied biological sciences. Psychology Genes, MHC Class I heat shock proteins HSP90 Heat-Shock Proteins - immunology Immune response Immune system Immunity Immunity, Cellular Immunity, Humoral Immunization immunoglobulin G Immunoglobulin G - blood interferon-gamma Interferon-gamma - immunology Lymphocytes maltose Maltose-Binding Proteins - immunology Medical research Mice Mice, Inbred BALB C Microbiology Nicotiana - chemistry Nicotiana benthamiana Peptides Plant Hsp90 Plant Proteins - immunology Plasmids Proteins recombinant proteins Recombinant Proteins - immunology Spleen - cytology Spleen - immunology splenocytes Vaccine vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) |
| title | Plant heat shock protein 90 as carrier-adjuvant for immunization against a reporter antigen |
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