Plant heat shock protein 90 as carrier-adjuvant for immunization against a reporter antigen

Highlights • We evaluate the adjuvant properties of heat shock protein 90 of Nicotiana benthamiana (NbHsp90.3). • Both humoral and cellular immune responses against MBP were elicited by administering the MBP-rNbHsp90.3 fusion protein. • The percentage of CD3+ CD8+ T cells significantly increased in...

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Veröffentlicht in:	Vaccine 2013-12, Vol.31 (49), p.5872-5878
Hauptverfasser:	Corigliano, Mariana G, Fenoy, Ignacio, Sander, Valeria, Maglioco, Andrea, Goldman, Alejandra, Clemente, Marina
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvant adjuvants Adjuvants, Immunologic - pharmacology Allergy and Immunology Animals Antigens Applied microbiology binding proteins Biological and medical sciences CD8-positive T-lymphocytes CD8-Positive T-Lymphocytes - immunology cell-mediated immunity Colleges & universities cytotoxicity Female Fundamental and applied biological sciences. Psychology Genes, MHC Class I heat shock proteins HSP90 Heat-Shock Proteins - immunology Immune response Immune system Immunity Immunity, Cellular Immunity, Humoral Immunization immunoglobulin G Immunoglobulin G - blood interferon-gamma Interferon-gamma - immunology Lymphocytes maltose Maltose-Binding Proteins - immunology Medical research Mice Mice, Inbred BALB C Microbiology Nicotiana - chemistry Nicotiana benthamiana Peptides Plant Hsp90 Plant Proteins - immunology Plasmids Proteins recombinant proteins Recombinant Proteins - immunology Spleen - cytology Spleen - immunology splenocytes Vaccine vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
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Zusammenfassung:	Highlights • We evaluate the adjuvant properties of heat shock protein 90 of Nicotiana benthamiana (NbHsp90.3). • Both humoral and cellular immune responses against MBP were elicited by administering the MBP-rNbHsp90.3 fusion protein. • The percentage of CD3+ CD8+ T cells significantly increased in MBP-rNbHsp90.3-immunized mice.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2013.09.047