Cross-protection provided by live Shigella mutants lacking major antigens

Abstract The immune response elicited by Shigella infections is dominated by serotype-specific antibodies recognizing the LPS O-antigens. Although a marked antibody response to invasion plasmid antigens (Ipa-s) shared by all virulent strains is also induced, the varying level of immunity elicited by...

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Veröffentlicht in:	International journal of medical microbiology 2013-05, Vol.303 (4), p.167-175
Hauptverfasser:	Szijártó, Valéria, Hunyadi-Gulyás, Éva, Emődy, Levente, Pál, Tibor, Nagy, Gábor
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Bacterial - genetics Antigens, Bacterial - immunology Cross Protection Disease Models, Animal Dysentery, Bacillary - immunology Dysentery, Bacillary - prevention & control Female Gene Deletion Immune response Infectious Disease Invasion plasmid Live vaccine LPS Medical Education Mice Mice, Inbred BALB C Mutation Shigella Shigella - genetics Shigella - immunology Shigella Vaccines - administration & dosage Shigella Vaccines - genetics Shigella Vaccines - immunology Vaccines, Attenuated - administration & dosage Vaccines, Attenuated - genetics Vaccines, Attenuated - immunology
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