Brain cortical thickness in the general elderly population: The Rotterdam Scan Study

•Increasing age is associated with thinning of the cerebral cortex, with the largest effects for the occipital and temporal lobes.•Female gender and higher education are demographic variables associated with a thicker cortex.•Diabetes mellitus is a strong risk factor of a thinner cortex. Cortical th...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Neuroscience letters 2013-08, Vol.550, p.189-194
Hauptverfasser: van Velsen, Evert F.S., Vernooij, Meike W., Vrooman, Henri A., van der Lugt, Aad, Breteler, Monique M.B., Hofman, Albert, Niessen, Wiro J., Ikram, M. Arfan
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:•Increasing age is associated with thinning of the cerebral cortex, with the largest effects for the occipital and temporal lobes.•Female gender and higher education are demographic variables associated with a thicker cortex.•Diabetes mellitus is a strong risk factor of a thinner cortex. Cortical thickness is considered a potentially relevant marker for neurodegenerative diseases. However, the relationship of demographic and vascular risk factors with cortical thickness remains unclear. In a population-based sample of 1022 non-demented elderly persons (mean age 68.4±7.3 years), we examined aging effects on global and lobar cortical thickness and the relationship with demographic variables and cardiovascular risk factors. We used a validated model-based approach to calculate mean cortical thickness (μm) in brain MR-images. We found that women had a significant thicker cortex than men (p
ISSN:0304-3940
1872-7972
DOI:10.1016/j.neulet.2013.06.063