Iron uptake and virulence in Histoplasma capsulatum

Iron uptake and virulence in Histoplasma capsulatum

Highlights • Iron is required for Hc survival and replication in macrophages. • Loss of the proton pump VMA1 disrupts iron acquisition and virulence both in MΦ and in mice. • Production of siderophores is required for survival in MΦ, and virulence in mice. • The ability to reduce ferric iron to the...

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Veröffentlicht in:Current opinion in microbiology 2013-12, Vol.16 (6), p.700-707
Hauptverfasser: Newman, Simon L, Smulian, A George
Format: Artikel
Sprache:eng
Schlagworte:
conidia
ferritin
Histoplasma - metabolism
Histoplasma - pathogenicity
Histoplasma capsulatum
histoplasmosis
ingestion
iron
Iron - metabolism
macrophages
Macrophages - microbiology
mammals
pathogens
Pathology
Phagosomes - microbiology
siderophores
therapeutics
Virulence
yeasts
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Beschreibung
Zusammenfassung:Highlights • Iron is required for Hc survival and replication in macrophages. • Loss of the proton pump VMA1 disrupts iron acquisition and virulence both in MΦ and in mice. • Production of siderophores is required for survival in MΦ, and virulence in mice. • The ability to reduce ferric iron to the ferrous is required for Hc survival in MΦ.
ISSN:1369-5274
1879-0364
DOI:10.1016/j.mib.2013.09.001