Iron acquisition in the human fungal pathogen Cryptococcus neoformans

Highlights • C. neoformans possesses high-affinity and low-affinity iron uptake systems. • The reductive high-affinity iron uptake system is required for virulence. • The regulation of iron uptake is mediated by a number of different regulatory proteins. • Microenvironmental conditions in the host i...

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Veröffentlicht in:	Current opinion in microbiology 2013-12, Vol.16 (6), p.686-691
Hauptverfasser:	Jung, Won Hee, Do, Eunsoo
Format:	Artikel
Sprache:	eng
Schlagworte:	animal pathogenic fungi Basidiomycetes Cryptococcus neoformans Cryptococcus neoformans - metabolism Cryptococcus neoformans - pathogenicity Cryptococcus neoformans - physiology hosts immunity Iron - metabolism Microbial Viability pathogenesis Pathology vertebrates Virulence
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Beschreibung
Zusammenfassung:	Highlights • C. neoformans possesses high-affinity and low-affinity iron uptake systems. • The reductive high-affinity iron uptake system is required for virulence. • The regulation of iron uptake is mediated by a number of different regulatory proteins. • Microenvironmental conditions in the host influence iron acquisition.
ISSN:	1369-5274 1879-0364
DOI:	10.1016/j.mib.2013.07.008