DEFB1 gene 5′ untranslated region (UTR) polymorphisms are marginally involved in inflammatory bowel disease in south Brazilians

Summary The possible association of three DEFB1 gene polymorphisms with susceptibility to develop ulcerative colitis (UC) and Crohn's disease (CD) was investigated in Brazilian patients and controls. Although a clear and strong association between functional 5′‐UTR DEFB1 SNPs and susceptibility...

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Veröffentlicht in:	International journal of immunogenetics 2014-04, Vol.41 (2), p.138-142
Hauptverfasser:	Wilson, T. J., Jobim, M., Segat, L., Bianco, A. M., Salim, P. H., Portela, P., Jobim, L. F., Damin, D. C., Schwartsmann, G., Roesler, R., Crovella, S.
Format:	Artikel
Sprache:	eng
Schlagworte:	5' Untranslated Regions Adult beta-Defensins - genetics Brazil Case-Control Studies Colitis, Ulcerative - genetics Crohn Disease - genetics Female Genetic Predisposition to Disease Genotype Humans Inflammatory Bowel Diseases - genetics Male Polymorphism, Single Nucleotide
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Zusammenfassung:	Summary The possible association of three DEFB1 gene polymorphisms with susceptibility to develop ulcerative colitis (UC) and Crohn's disease (CD) was investigated in Brazilian patients and controls. Although a clear and strong association between functional 5′‐UTR DEFB1 SNPs and susceptibility/protection to IBDs cannot be drawn, our results suggest a possible involvement of DEFB1 gene in inflammatory bowel diseases, especially with the colonic localization of Crohn's disease.
ISSN:	1744-3121 1744-313X
DOI:	10.1111/iji.12089