PcrV antibody protects multi-drug resistant Pseudomonas aeruginosa induced acute lung injury

Highlights • We analyzed the expression level of TTSS in clinically isolated multi-drug resistant Pseudomonas aeruginsoa strains and compared it with susceptible strains. • We investigated the effect of PcrV antibody on multi-drug resistant Pseudomonas aeruginosa induced acute lung injury. • The TTS...

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Veröffentlicht in:	Respiratory physiology & neurobiology 2014-03, Vol.193, p.21-28
Hauptverfasser:	Wang, Qin, Li, Huayin, Zhou, Jian, Zhong, Ming, Zhu, Duming, Feng, Nana, Liu, Fanglei, Bai, Chunxue, Song, Yuanlin
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Lung Injury - drug therapy Acute Lung Injury - etiology Acute Lung Injury - pathology Acute Lung Injury - therapy ADP Ribose Transferases - metabolism Animals Anti-Bacterial Agents - therapeutic use Antibodies, Bacterial - therapeutic use Antigens, Bacterial - immunology Bacterial Proteins - metabolism Bacterial Secretion Systems - physiology Bacterial Toxins - immunology Bacterial Toxins - metabolism Ceftazidime - therapeutic use Cytokines - blood Drug Resistance, Multiple, Bacterial Gene Expression Immunization, Passive Lung - drug effects Lung - immunology Lung - pathology Mab166 Medical Education Mice Mice, Inbred BALB C Multi-drug resistance Neutrophils - immunology PcrV Pore Forming Cytotoxic Proteins - immunology Pseudomonas aeruginosa Pseudomonas aeruginosa - drug effects Pseudomonas aeruginosa - pathogenicity Pseudomonas Infections - complications Pseudomonas Infections - drug therapy Pseudomonas Infections - pathology Pseudomonas Infections - therapy Pulmonary/Respiratory Species Specificity Survival Analysis Type III secretion system
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Zusammenfassung:	Highlights • We analyzed the expression level of TTSS in clinically isolated multi-drug resistant Pseudomonas aeruginsoa strains and compared it with susceptible strains. • We investigated the effect of PcrV antibody on multi-drug resistant Pseudomonas aeruginosa induced acute lung injury. • The TTSS is comparatively conservative without correlation with antimicrobial resistance. • PcrV antibody could protect multi-drug resistant Pseudomonas aeruginosa induced acute lung injury.
ISSN:	1569-9048 1878-1519
DOI:	10.1016/j.resp.2014.01.001