Photoprotective activity of resveratrol analogues

Resveratrol is a promising agent for protecting human skin from UV radiation and to reduce the occurrence of cutaneous malignancies. We describe the photoprotective activity of six resveratrol analogues using the diffuse transmittance technique to determine the SPF and the protection against UVA rad...

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Veröffentlicht in:Bioorganic & medicinal chemistry 2013-02, Vol.21 (4), p.964-968
Hauptverfasser: Polonini, Hudson Caetano, Lima, Larissa Lavorato, Gonçalves, Karla Mara, do Carmo, Antônio Márcio Resende, da Silva, Adilson David, Raposo, Nádia Rezende Barbosa
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Sprache:eng
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Zusammenfassung:Resveratrol is a promising agent for protecting human skin from UV radiation and to reduce the occurrence of cutaneous malignancies. We describe the photoprotective activity of six resveratrol analogues using the diffuse transmittance technique to determine the SPF and the protection against UVA radiation. The analogues presented a varied profile of photoprotection, the SPF ranging from 2 to 10 and the UVAPF from 0 to 9. Among the six compounds tested, the protection against UVB sunrays provided by compound B was more significant than the protection provided by resveratrol; compounds C, D, E and F show photoprotection similar to resveratrol.
ISSN:0968-0896
1464-3391
DOI:10.1016/j.bmc.2012.11.052