Intramyocardial autologous bone marrow cell transplantation for ischemic heart disease: A systematic review and meta-analysis of randomized controlled trials
Abstract Objective This study was undertaken to evaluate the efficacy of intramyocardial bone marrow cell (BMC) transplant therapy for ischemic heart disease (IHD). Methods The PubMed, Embase, and Cochrane Library databases through October 2013 were searched for randomized clinical trials (RCTs) of...
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| Veröffentlicht in: | Atherosclerosis 2014-04, Vol.233 (2), p.485-492 |
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| creator | Tian, Tao Chen, Bingwei Xiao, Yan Yang, Kunqi Zhou, Xianliang |
| description | Abstract Objective This study was undertaken to evaluate the efficacy of intramyocardial bone marrow cell (BMC) transplant therapy for ischemic heart disease (IHD). Methods The PubMed, Embase, and Cochrane Library databases through October 2013 were searched for randomized clinical trials (RCTs) of intramyocardial BMCs to treat IHD. The primary endpoint was change in left ventricular ejection fraction (LVEF). Secondary endpoints were changes in left ventricular end-systolic volume (LVESV) and left ventricular end-diastolic volume (LVEDV). Weighted mean differences for the changes were estimated with a random-effects model. Results Eleven RCTs with 492 participants were included. Intramyocardial BMC transplantation increased LVEF (4.91%; 95% confidence interval [CI] 2.84%–6.99%; P |
| doi_str_mv | 10.1016/j.atherosclerosis.2014.01.027 |
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| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1520350429</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0021915014000525</els_id><sourcerecordid>1520350429</sourcerecordid><originalsourceid>FETCH-LOGICAL-c510t-695b26fd952b2109d721ca7bb80fbdfec2effffe16b824db114541bfd8080c243</originalsourceid><addsrcrecordid>eNqNUk1vEzEQXSEQDYW_gHxB4rJhxvFmd5FAqioolSpxAM6W154lDt51sJ1W4b_wX5kohUNP-OCZw5uP995U1SuEJQKu32yXpmwoxWzD8fd5KQHVEnAJsn1ULbBr-xpVpx5XCwCJdY8NnFXPct4CgGqxe1qdSdWsoO1Wi-r39VySmQ7RmuS8CcLsSwzxe9xnMcSZxGRSinfCUgiCkXPeBTMXU3ycxRiT8NluaPJWbMikIpzPZDK9FRciH3KhiZFWJLr1dCfM7MRExdRmNuHAu4s4Cu7p4uR_kRM28jIxBE5L4mXy8-rJyIFe3Mfz6tvHD18vP9U3n6-uLy9uatsglHrdN4Ncj65v5CARetdKtKYdhg7GwY1kJY38CNdDJ5UbEFWjcBhdBx1YqVbn1etT312KP_eUi56YF1M2M7ESGhsJqwaU7Bn67gS1rH5ONOpd8izSQSPoo0N6qx84pI8OaUDNDnH9y_tR-2Ei96_6ryUMuDoBiAmzbEln62m25HwiW7SL_r9HvX_QyQY_e2vCDzpQ3sZ9Yh-Ync5Sg_5yPJfjtaDiS2lks_oD7aXGVg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1520350429</pqid></control><display><type>article</type><title>Intramyocardial autologous bone marrow cell transplantation for ischemic heart disease: A systematic review and meta-analysis of randomized controlled trials</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Tian, Tao ; Chen, Bingwei ; Xiao, Yan ; Yang, Kunqi ; Zhou, Xianliang</creator><creatorcontrib>Tian, Tao ; Chen, Bingwei ; Xiao, Yan ; Yang, Kunqi ; Zhou, Xianliang</creatorcontrib><description>Abstract Objective This study was undertaken to evaluate the efficacy of intramyocardial bone marrow cell (BMC) transplant therapy for ischemic heart disease (IHD). Methods The PubMed, Embase, and Cochrane Library databases through October 2013 were searched for randomized clinical trials (RCTs) of intramyocardial BMCs to treat IHD. The primary endpoint was change in left ventricular ejection fraction (LVEF). Secondary endpoints were changes in left ventricular end-systolic volume (LVESV) and left ventricular end-diastolic volume (LVEDV). Weighted mean differences for the changes were estimated with a random-effects model. Results Eleven RCTs with 492 participants were included. Intramyocardial BMC transplantation increased LVEF (4.91%; 95% confidence interval [CI] 2.84%–6.99%; P < 0.00001), reduced LVESV (10.66 mL; 95% CI, −18.92 mL to −2.41 mL; P = 0.01), and showed a trend toward decreased LVEDV (−7.82 mL; 95% CI, −16.36 mL–0.71 mL; P = 0.07). Patients suitable for revascularization with coronary artery bypass grafting had greater improvement in LVEF (7.60%; 95% CI, 4.74%–10.46%, P < 0.00001) than those unsuitable for revascularization (3.76%; 95% CI, 2.20%–5.32%; P < 0.00001). LVEDV reduction was also more significant in revascularizable IHD (−16.51 mL; 95% CI, −22.05 mL to −10.07 mL; P < 0.00001) than non-revascularizable IHD (−0.89 mL; 95% CI, −8.44 mL–6.66 mL; P = 0.82). Conclusion Intramyocardial BMC injection contributes to improvement in left ventricular dysfunction and reduction in left ventricular volume. Patients with revascularizable IHD may benefit more from this therapy.</description><identifier>ISSN: 0021-9150</identifier><identifier>EISSN: 1879-1484</identifier><identifier>DOI: 10.1016/j.atherosclerosis.2014.01.027</identifier><identifier>PMID: 24530783</identifier><language>eng</language><publisher>Ireland: Elsevier B.V</publisher><subject>Bone marrow cells ; Bone Marrow Transplantation ; Cardiovascular ; Coronary Artery Bypass ; Heart failure ; Humans ; Injections ; Meta-analysis ; Models, Cardiovascular ; Myocardial ischemia ; Myocardial Ischemia - complications ; Myocardial Ischemia - physiopathology ; Myocardial Ischemia - surgery ; Myocardium ; Postoperative Complications - epidemiology ; Publication Bias ; Randomized Controlled Trials as Topic - methods ; Randomized Controlled Trials as Topic - statistics & numerical data ; Research Design ; Stem cells ; Stroke Volume ; Transplantation, Autologous ; Treatment Outcome ; Ventricular Dysfunction, Left - etiology ; Ventricular Dysfunction, Left - physiopathology ; Ventricular Dysfunction, Left - surgery ; Ventricular Remodeling</subject><ispartof>Atherosclerosis, 2014-04, Vol.233 (2), p.485-492</ispartof><rights>Elsevier Ireland Ltd</rights><rights>2014 Elsevier Ireland Ltd</rights><rights>Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c510t-695b26fd952b2109d721ca7bb80fbdfec2effffe16b824db114541bfd8080c243</citedby><cites>FETCH-LOGICAL-c510t-695b26fd952b2109d721ca7bb80fbdfec2effffe16b824db114541bfd8080c243</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.atherosclerosis.2014.01.027$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,782,786,3552,27931,27932,46002</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24530783$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tian, Tao</creatorcontrib><creatorcontrib>Chen, Bingwei</creatorcontrib><creatorcontrib>Xiao, Yan</creatorcontrib><creatorcontrib>Yang, Kunqi</creatorcontrib><creatorcontrib>Zhou, Xianliang</creatorcontrib><title>Intramyocardial autologous bone marrow cell transplantation for ischemic heart disease: A systematic review and meta-analysis of randomized controlled trials</title><title>Atherosclerosis</title><addtitle>Atherosclerosis</addtitle><description>Abstract Objective This study was undertaken to evaluate the efficacy of intramyocardial bone marrow cell (BMC) transplant therapy for ischemic heart disease (IHD). Methods The PubMed, Embase, and Cochrane Library databases through October 2013 were searched for randomized clinical trials (RCTs) of intramyocardial BMCs to treat IHD. The primary endpoint was change in left ventricular ejection fraction (LVEF). Secondary endpoints were changes in left ventricular end-systolic volume (LVESV) and left ventricular end-diastolic volume (LVEDV). Weighted mean differences for the changes were estimated with a random-effects model. Results Eleven RCTs with 492 participants were included. Intramyocardial BMC transplantation increased LVEF (4.91%; 95% confidence interval [CI] 2.84%–6.99%; P < 0.00001), reduced LVESV (10.66 mL; 95% CI, −18.92 mL to −2.41 mL; P = 0.01), and showed a trend toward decreased LVEDV (−7.82 mL; 95% CI, −16.36 mL–0.71 mL; P = 0.07). Patients suitable for revascularization with coronary artery bypass grafting had greater improvement in LVEF (7.60%; 95% CI, 4.74%–10.46%, P < 0.00001) than those unsuitable for revascularization (3.76%; 95% CI, 2.20%–5.32%; P < 0.00001). LVEDV reduction was also more significant in revascularizable IHD (−16.51 mL; 95% CI, −22.05 mL to −10.07 mL; P < 0.00001) than non-revascularizable IHD (−0.89 mL; 95% CI, −8.44 mL–6.66 mL; P = 0.82). Conclusion Intramyocardial BMC injection contributes to improvement in left ventricular dysfunction and reduction in left ventricular volume. Patients with revascularizable IHD may benefit more from this therapy.</description><subject>Bone marrow cells</subject><subject>Bone Marrow Transplantation</subject><subject>Cardiovascular</subject><subject>Coronary Artery Bypass</subject><subject>Heart failure</subject><subject>Humans</subject><subject>Injections</subject><subject>Meta-analysis</subject><subject>Models, Cardiovascular</subject><subject>Myocardial ischemia</subject><subject>Myocardial Ischemia - complications</subject><subject>Myocardial Ischemia - physiopathology</subject><subject>Myocardial Ischemia - surgery</subject><subject>Myocardium</subject><subject>Postoperative Complications - epidemiology</subject><subject>Publication Bias</subject><subject>Randomized Controlled Trials as Topic - methods</subject><subject>Randomized Controlled Trials as Topic - statistics & numerical data</subject><subject>Research Design</subject><subject>Stem cells</subject><subject>Stroke Volume</subject><subject>Transplantation, Autologous</subject><subject>Treatment Outcome</subject><subject>Ventricular Dysfunction, Left - etiology</subject><subject>Ventricular Dysfunction, Left - physiopathology</subject><subject>Ventricular Dysfunction, Left - surgery</subject><subject>Ventricular Remodeling</subject><issn>0021-9150</issn><issn>1879-1484</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUk1vEzEQXSEQDYW_gHxB4rJhxvFmd5FAqioolSpxAM6W154lDt51sJ1W4b_wX5kohUNP-OCZw5uP995U1SuEJQKu32yXpmwoxWzD8fd5KQHVEnAJsn1ULbBr-xpVpx5XCwCJdY8NnFXPct4CgGqxe1qdSdWsoO1Wi-r39VySmQ7RmuS8CcLsSwzxe9xnMcSZxGRSinfCUgiCkXPeBTMXU3ycxRiT8NluaPJWbMikIpzPZDK9FRciH3KhiZFWJLr1dCfM7MRExdRmNuHAu4s4Cu7p4uR_kRM28jIxBE5L4mXy8-rJyIFe3Mfz6tvHD18vP9U3n6-uLy9uatsglHrdN4Ncj65v5CARetdKtKYdhg7GwY1kJY38CNdDJ5UbEFWjcBhdBx1YqVbn1etT312KP_eUi56YF1M2M7ESGhsJqwaU7Bn67gS1rH5ONOpd8izSQSPoo0N6qx84pI8OaUDNDnH9y_tR-2Ei96_6ryUMuDoBiAmzbEln62m25HwiW7SL_r9HvX_QyQY_e2vCDzpQ3sZ9Yh-Ync5Sg_5yPJfjtaDiS2lks_oD7aXGVg</recordid><startdate>20140401</startdate><enddate>20140401</enddate><creator>Tian, Tao</creator><creator>Chen, Bingwei</creator><creator>Xiao, Yan</creator><creator>Yang, Kunqi</creator><creator>Zhou, Xianliang</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20140401</creationdate><title>Intramyocardial autologous bone marrow cell transplantation for ischemic heart disease: A systematic review and meta-analysis of randomized controlled trials</title><author>Tian, Tao ; Chen, Bingwei ; Xiao, Yan ; Yang, Kunqi ; Zhou, Xianliang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c510t-695b26fd952b2109d721ca7bb80fbdfec2effffe16b824db114541bfd8080c243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Bone marrow cells</topic><topic>Bone Marrow Transplantation</topic><topic>Cardiovascular</topic><topic>Coronary Artery Bypass</topic><topic>Heart failure</topic><topic>Humans</topic><topic>Injections</topic><topic>Meta-analysis</topic><topic>Models, Cardiovascular</topic><topic>Myocardial ischemia</topic><topic>Myocardial Ischemia - complications</topic><topic>Myocardial Ischemia - physiopathology</topic><topic>Myocardial Ischemia - surgery</topic><topic>Myocardium</topic><topic>Postoperative Complications - epidemiology</topic><topic>Publication Bias</topic><topic>Randomized Controlled Trials as Topic - methods</topic><topic>Randomized Controlled Trials as Topic - statistics & numerical data</topic><topic>Research Design</topic><topic>Stem cells</topic><topic>Stroke Volume</topic><topic>Transplantation, Autologous</topic><topic>Treatment Outcome</topic><topic>Ventricular Dysfunction, Left - etiology</topic><topic>Ventricular Dysfunction, Left - physiopathology</topic><topic>Ventricular Dysfunction, Left - surgery</topic><topic>Ventricular Remodeling</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tian, Tao</creatorcontrib><creatorcontrib>Chen, Bingwei</creatorcontrib><creatorcontrib>Xiao, Yan</creatorcontrib><creatorcontrib>Yang, Kunqi</creatorcontrib><creatorcontrib>Zhou, Xianliang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Atherosclerosis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tian, Tao</au><au>Chen, Bingwei</au><au>Xiao, Yan</au><au>Yang, Kunqi</au><au>Zhou, Xianliang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intramyocardial autologous bone marrow cell transplantation for ischemic heart disease: A systematic review and meta-analysis of randomized controlled trials</atitle><jtitle>Atherosclerosis</jtitle><addtitle>Atherosclerosis</addtitle><date>2014-04-01</date><risdate>2014</risdate><volume>233</volume><issue>2</issue><spage>485</spage><epage>492</epage><pages>485-492</pages><issn>0021-9150</issn><eissn>1879-1484</eissn><abstract>Abstract Objective This study was undertaken to evaluate the efficacy of intramyocardial bone marrow cell (BMC) transplant therapy for ischemic heart disease (IHD). Methods The PubMed, Embase, and Cochrane Library databases through October 2013 were searched for randomized clinical trials (RCTs) of intramyocardial BMCs to treat IHD. The primary endpoint was change in left ventricular ejection fraction (LVEF). Secondary endpoints were changes in left ventricular end-systolic volume (LVESV) and left ventricular end-diastolic volume (LVEDV). Weighted mean differences for the changes were estimated with a random-effects model. Results Eleven RCTs with 492 participants were included. Intramyocardial BMC transplantation increased LVEF (4.91%; 95% confidence interval [CI] 2.84%–6.99%; P < 0.00001), reduced LVESV (10.66 mL; 95% CI, −18.92 mL to −2.41 mL; P = 0.01), and showed a trend toward decreased LVEDV (−7.82 mL; 95% CI, −16.36 mL–0.71 mL; P = 0.07). Patients suitable for revascularization with coronary artery bypass grafting had greater improvement in LVEF (7.60%; 95% CI, 4.74%–10.46%, P < 0.00001) than those unsuitable for revascularization (3.76%; 95% CI, 2.20%–5.32%; P < 0.00001). LVEDV reduction was also more significant in revascularizable IHD (−16.51 mL; 95% CI, −22.05 mL to −10.07 mL; P < 0.00001) than non-revascularizable IHD (−0.89 mL; 95% CI, −8.44 mL–6.66 mL; P = 0.82). Conclusion Intramyocardial BMC injection contributes to improvement in left ventricular dysfunction and reduction in left ventricular volume. Patients with revascularizable IHD may benefit more from this therapy.</abstract><cop>Ireland</cop><pub>Elsevier B.V</pub><pmid>24530783</pmid><doi>10.1016/j.atherosclerosis.2014.01.027</doi><tpages>8</tpages></addata></record> |
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| subjects | Bone marrow cells Bone Marrow Transplantation Cardiovascular Coronary Artery Bypass Heart failure Humans Injections Meta-analysis Models, Cardiovascular Myocardial ischemia Myocardial Ischemia - complications Myocardial Ischemia - physiopathology Myocardial Ischemia - surgery Myocardium Postoperative Complications - epidemiology Publication Bias Randomized Controlled Trials as Topic - methods Randomized Controlled Trials as Topic - statistics & numerical data Research Design Stem cells Stroke Volume Transplantation, Autologous Treatment Outcome Ventricular Dysfunction, Left - etiology Ventricular Dysfunction, Left - physiopathology Ventricular Dysfunction, Left - surgery Ventricular Remodeling |
| title | Intramyocardial autologous bone marrow cell transplantation for ischemic heart disease: A systematic review and meta-analysis of randomized controlled trials |
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