Intramyocardial autologous bone marrow cell transplantation for ischemic heart disease: A systematic review and meta-analysis of randomized controlled trials

Abstract Objective This study was undertaken to evaluate the efficacy of intramyocardial bone marrow cell (BMC) transplant therapy for ischemic heart disease (IHD). Methods The PubMed, Embase, and Cochrane Library databases through October 2013 were searched for randomized clinical trials (RCTs) of...

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Veröffentlicht in:	Atherosclerosis 2014-04, Vol.233 (2), p.485-492
Hauptverfasser:	Tian, Tao, Chen, Bingwei, Xiao, Yan, Yang, Kunqi, Zhou, Xianliang
Format:	Artikel
Sprache:	eng
Schlagworte:	Bone marrow cells Bone Marrow Transplantation Cardiovascular Coronary Artery Bypass Heart failure Humans Injections Meta-analysis Models, Cardiovascular Myocardial ischemia Myocardial Ischemia - complications Myocardial Ischemia - physiopathology Myocardial Ischemia - surgery Myocardium Postoperative Complications - epidemiology Publication Bias Randomized Controlled Trials as Topic - methods Randomized Controlled Trials as Topic - statistics & numerical data Research Design Stem cells Stroke Volume Transplantation, Autologous Treatment Outcome Ventricular Dysfunction, Left - etiology Ventricular Dysfunction, Left - physiopathology Ventricular Dysfunction, Left - surgery Ventricular Remodeling
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Zusammenfassung:	Abstract Objective This study was undertaken to evaluate the efficacy of intramyocardial bone marrow cell (BMC) transplant therapy for ischemic heart disease (IHD). Methods The PubMed, Embase, and Cochrane Library databases through October 2013 were searched for randomized clinical trials (RCTs) of intramyocardial BMCs to treat IHD. The primary endpoint was change in left ventricular ejection fraction (LVEF). Secondary endpoints were changes in left ventricular end-systolic volume (LVESV) and left ventricular end-diastolic volume (LVEDV). Weighted mean differences for the changes were estimated with a random-effects model. Results Eleven RCTs with 492 participants were included. Intramyocardial BMC transplantation increased LVEF (4.91%; 95% confidence interval [CI] 2.84%–6.99%; P
ISSN:	0021-9150 1879-1484
DOI:	10.1016/j.atherosclerosis.2014.01.027