β-Lactamase induction and resistance to β-lactam antibiotics

Certain bacteria including Enterobacter spp. and Ps. aeruginosa typically produce a beta -lactamase inducibly but that such cultures also frequently contain a minority population of mutants which produce the same type of beta lactamase at a high level constitutively and it is the selection of these...

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Veröffentlicht in:	Journal of antimicrobial chemotherapy 1989-01, Vol.23 (1), p.1-3
1. Verfasser:	ROLINSON, G. N
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - pharmacology Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents beta-Lactamases - biosynthesis beta-Lactams Biological and medical sciences Drug Resistance, Microbial Enterobacter - drug effects Enterobacteriaceae - drug effects Medical sciences Pharmacology. Drug treatments Pseudomonas aeruginosa Pseudomonas aeruginosa - drug effects
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Beschreibung
Zusammenfassung:	Certain bacteria including Enterobacter spp. and Ps. aeruginosa typically produce a beta -lactamase inducibly but that such cultures also frequently contain a minority population of mutants which produce the same type of beta lactamase at a high level constitutively and it is the selection of these derepressed mutants that is responsible for the emergence of resistance in the clinic, not the phenomenon of beta -lactamase induction.
ISSN:	0305-7453 1460-2091
DOI:	10.1093/jac/23.1.1