A Furostanol Glycoside from Garlic, Bulbs of Allium sativum L

A Furostanol Glycoside from Garlic, Bulbs of Allium sativum L

A new furostanol glycoside (1) was isolated from garlic, bulbs of Allium sativum L. (Liliaceae), and the structure was established to be 26-O-β-glucopyranosyl 22-hydroxy-25(R)-5α-furostane-3β, 6β, 26-triol 3-O-β-glucopyranosyl(1→2)-[β-glucopyranosyl(1→3)]-β-glucopyranosyl-(1→4)-β-galactopyranoside,...

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Veröffentlicht in:Chemical & pharmaceutical bulletin 1988/09/25, Vol.36(9), pp.3659-3663
Hauptverfasser: MATSUURA, HIROMICHI, USHIROGUCHI, TSUYOSHI, ITAKURA, YOICHI, HAYASHI, NORIHIRO, FUWA, TORU
Format: Artikel
Sprache:eng
Schlagworte:
antifungal activity
Biological and medical sciences
Candida albicans
Medical sciences
Pharmacology. Drug treatments
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Zusammenfassung:A new furostanol glycoside (1) was isolated from garlic, bulbs of Allium sativum L. (Liliaceae), and the structure was established to be 26-O-β-glucopyranosyl 22-hydroxy-25(R)-5α-furostane-3β, 6β, 26-triol 3-O-β-glucopyranosyl(1→2)-[β-glucopyranosyl(1→3)]-β-glucopyranosyl-(1→4)-β-galactopyranoside, i.e., proto-eruboside-B. Eruboside-B (3) obtained by enzymatic hydrolysis of 1 inhibited the growth of Candida albicans in vitro (25 μg/ml MIC).
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.36.3659