Antiangiogenic Activity of Hypoxylonol C

Hypoxylonol C (1), isolated from the inedible mushroom Hypoxylon truncatum, exhibited inhibitory activities against the migration and tube formation of HUVECs. A cDNA microarray analysis was performed to investigate the target of hypoxylonol C (1) in HUVECs, and it was found that the genes related t...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2014-04, Vol.77 (4), p.1065-1068
Hauptverfasser:	Fukai, Miyuki, Suzuki, Toshihiro, Nagasawa, Ikuko, Kinoshita, Kaoru, Takahashi, Kunio, Koyama, Kiyotaka
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Inhibitors - genetics Angiogenesis Inhibitors - isolation & purification Angiogenesis Inhibitors - pharmacology Apoptosis - drug effects Cell Adhesion - drug effects Cell Cycle - drug effects Cell Movement - drug effects Cell Proliferation - drug effects Dose-Response Relationship, Drug Fluorenes - chemistry Fluorenes - isolation & purification Fluorenes - pharmacology Human Umbilical Vein Endothelial Cells - drug effects Humans Molecular Structure Vascular Endothelial Growth Factor A - pharmacology
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Zusammenfassung:	Hypoxylonol C (1), isolated from the inedible mushroom Hypoxylon truncatum, exhibited inhibitory activities against the migration and tube formation of HUVECs. A cDNA microarray analysis was performed to investigate the target of hypoxylonol C (1) in HUVECs, and it was found that the genes related to cell cycle and adhesion were down-regulated. The down-regulation of mRNA levels of cell cycle and adhesion genes was confirmed by real-time RT-PCR. Cell cycle arrest and suppression of adhesion molecule expression might be plausible mechanisms of actions for the antiangiogenic activity of hypoxylonol C (1).
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np400687y