Transitioning from genotypes to epigenotypes: Why the time has come for medulloblastoma epigenomics

Transitioning from genotypes to epigenotypes: Why the time has come for medulloblastoma epigenomics

Highlights • Medulloblastomas exhibit frequent somatic alterations affecting chromatin modifiers. • Epigenetic profiling provides accurate molecular subgrouping of medulloblastoma. • Epigenome-wide studies using WGBS & ChIPSeq are now being applied to medulloblastoma. • Epigenetic therapy holds...

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Veröffentlicht in:Neuroscience 2014-04, Vol.264, p.171-185
Hauptverfasser: Batora, N.V, Sturm, D, Jones, D.T.W, Kool, M, Pfister, S.M, Northcott, P.A
Format: Artikel
Sprache:eng
Schlagworte:
Cerebellar Neoplasms - genetics
Child
Epigenesis, Genetic
Epigenomics
Genotype
Humans
Medulloblastoma - genetics
Neurology
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Zusammenfassung:Highlights • Medulloblastomas exhibit frequent somatic alterations affecting chromatin modifiers. • Epigenetic profiling provides accurate molecular subgrouping of medulloblastoma. • Epigenome-wide studies using WGBS & ChIPSeq are now being applied to medulloblastoma. • Epigenetic therapy holds great promise for the future treatment of medulloblastoma.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2013.07.030