Anti-inflammatory Labdane Diterpenoids from Lagopsis supina

Ten new labdane diterpenoids, lagopsins A–H (1–3, 5, 7–10) and 15-epi-lagopsins C and D (4, 6), together with five known labdane diterpenoids (11–15), were isolated from the whole plants of Lagopsis supina. The absolute configuration of lagopsin A (1) was determined by single-crystal X-ray crystallo...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2014-04, Vol.77 (4), p.1047-1053
Hauptverfasser:	Li, Hui, Li, Man-Man, Su, Xiao-Qin, Sun, Jing, Gu, Yu-Fan, Zeng, Ke-Wu, Zhang, Qian, Zhao, Yun-Fang, Ferreira, Daneel, Zjawiony, Jordan K, Li, Jun, Tu, Peng-Fei
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - chemistry Anti-Inflammatory Agents - isolation & purification Anti-Inflammatory Agents - pharmacology Crystallography, X-Ray Diterpenes - chemistry Diterpenes - isolation & purification Diterpenes - pharmacology Drugs, Chinese Herbal - chemistry Drugs, Chinese Herbal - isolation & purification Drugs, Chinese Herbal - pharmacology Lamiaceae - chemistry Lipopolysaccharides - pharmacology Macrophages - drug effects Mice Molecular Conformation Molecular Structure Nitric Oxide - biosynthesis Plant Leaves - chemistry
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Zusammenfassung:	Ten new labdane diterpenoids, lagopsins A–H (1–3, 5, 7–10) and 15-epi-lagopsins C and D (4, 6), together with five known labdane diterpenoids (11–15), were isolated from the whole plants of Lagopsis supina. The absolute configuration of lagopsin A (1) was determined by single-crystal X-ray crystallographic analysis. Compounds 7, 9, 13, and 15 exhibited moderate inhibition of nitric oxide production stimulated by lipopolysaccharide in BV-2 microglial cells with IC50 values in the range 14.9–34.9 μM.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np5001329