Asymmetric synthesis of heteroaryl atropisomers via a gold-catalyzed cycloisomerization-amination cascade reaction

Asymmetric synthesis of heteroaryl atropisomers via a gold-catalyzed cycloisomerization-amination cascade reaction

The chiral gold(i) complex enables enantioselective cycloisomerization-amination of 2-(alkynyl)phenyl boronic acids and diazenes in high yields. A wide scope of substrates bearing various functional groups was tolerated to generate structurally different hydrazide derivatives as a new type of atropi...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2014-01, Vol.50 (41), p.5451-5454
Hauptverfasser: Guo, Rui, Li, Kang-Nan, Liu, Bin, Zhu, Hua-Jie, Fan, Yu-Meng, Gong, Liu-Zhu
Format: Artikel
Sprache:eng
Schlagworte:
Amination
Boronic Acids - chemistry
Catalysis
Chemistry Techniques, Synthetic
Gold - chemistry
Heterocyclic Compounds - chemical synthesis
Heterocyclic Compounds - chemistry
Imides - chemistry
Stereoisomerism
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Beschreibung
Zusammenfassung:The chiral gold(i) complex enables enantioselective cycloisomerization-amination of 2-(alkynyl)phenyl boronic acids and diazenes in high yields. A wide scope of substrates bearing various functional groups was tolerated to generate structurally different hydrazide derivatives as a new type of atropisomer.
ISSN:1359-7345
1364-548X
DOI:10.1039/c4cc01397b