Vitamin E improved cypermethrin-induced damages in the ovary of rats; evidence for angiogenesis and p53 involvement

•RNA damages in follicular cells.•Reduced angiogenesis and over-expression of pro-apoptotic gene of p53.•A significant decline of the serum levels of gonadotropins.•Ultimately, VitE could fairly enhance the CPM-reduced angiogenesis and down-regulate the p53 over expression. This study aimed to investigate the protective effect of vitamin E (VitE) on cypermethrin (CPM)-induced damages in the ovary. Wistar rats were divided into seven groups (n=6) including; control-sham (c), CPM-received (CPM, 75mg/kg, i.p.), and CPM and VitE-treated (VitE, 150mg/kg, orally) for 7, 14 and 24days. The antioxidant status determination and hormonal assays along with histological and immunofluorescent assessments were performed. The expression of p53 at mRNA level was also examined. The CPM administration affected the ovarian structure and functions as it elevated the follicular atresia and significantly (P