Chronobiological approach to aminoglycosides

Aminoglycoside antibiotics are widely used for the treatment of severe gram-negative bacterial infections. Because nephrotoxicity may limit the clinical use of aminoglycosides, recognition of factors associated with a greater incidence of renal damage is important. The present study aimed to exhibit a circadian rhythm in amikacin-induced nephrotoxicity when the drug was administered at different times of the day in rats, by sublethal and prolonged regimens. This was especially assessed by enzymuria estimation.