Cordyceps militaris polysaccharides can enhance the immunity and antioxidation activity in immunosuppressed mice

► Immunosuppressed mice was administrated Cordyceps militaris polysaccharides (CMP). ► CMP can overcome the cyclophosphamide-induced immunosuppression. ► Enhancing spleen lymphocyte activity and macrophage function. ► Raising the SOD, CAT, GSH-Px and TAOC level and the spleen and thymus indices. ► D...

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Veröffentlicht in:Carbohydrate polymers 2012-06, Vol.89 (2), p.461-466
Hauptverfasser: Wang, Mi, Meng, Xin Yu, Yang, Rui Le, Qin, Tao, Wang, Xiao Yang, Zhang, Ke Yu, Fei, Chen Zhong, Li, Ying, Hu, Yuan liang, Xue, Fei Qun
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Sprache:eng
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Zusammenfassung:► Immunosuppressed mice was administrated Cordyceps militaris polysaccharides (CMP). ► CMP can overcome the cyclophosphamide-induced immunosuppression. ► Enhancing spleen lymphocyte activity and macrophage function. ► Raising the SOD, CAT, GSH-Px and TAOC level and the spleen and thymus indices. ► Decreasing MDA level. To evaluate the immune activation and reactive oxygen species scavenging activity of Cordyceps militaris polysaccharides (CMP) in vivo, 90 male BALB/c mice were randomly divided into six groups. The mice in the three experimental groups were given cyclophosphamide at 80mg/kg/d via intraperitoneal injection and 17.5, 35, or 70mg/kg body weight CMP via gavage. The lymphocyte proliferation, phagocytic index, and biochemical parameters were measured. The results show that the administration of CMP was able to overcome the CY-induced immunosuppression, significantly increased the spleen and thymus indices, and enhanced the spleen lymphocyte activity and macrophage function. CMP can also improve the antioxidation activity in immunosuppressed mice, significantly increase the superoxidase dismutase, catalase, and glutathione peroxidase levels and the total antioxidant capacity, and decrease the malondialdehyde levels in vivo.
ISSN:0144-8617
1879-1344
DOI:10.1016/j.carbpol.2012.03.029